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A critical evaluation of the evidence on a causal relationship between Helicobacter pylori and otitis media with effusion

Published online by Cambridge University Press:  26 November 2007

H Sudhoff ,
S Rajagopal ,
D M Baguley ,
J Ebmeyer ,
A Schmelzer ,
S Schreiber  and
D A Moffat
H Sudhoff*
Affiliation:
Departments of Otolaryngology and Skull Base Surgery, Addenbrooke's Hospital, Cambridge, UK Department of Otolaryngology, Head and Neck Surgery, Städtische Kliniken Bielefeld, Bielefeld, Germany
S Rajagopal
Affiliation:
Departments of Otolaryngology and Skull Base Surgery, Addenbrooke's Hospital, Cambridge, UK
D M Baguley
Affiliation:
Department of Audiology, Addenbrooke's Hospital, Cambridge, UK
J Ebmeyer
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Städtische Kliniken Bielefeld, Bielefeld, Germany
A Schmelzer
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Städtische Kliniken Bielefeld, Bielefeld, Germany
S Schreiber
Affiliation:
Institut für Physiologie, Ruhr-Universität Bochum, Germany
D A Moffat
Affiliation:
Departments of Otolaryngology and Skull Base Surgery, Addenbrooke's Hospital, Cambridge, UK
*
Address for correspondence: Professor Dr Holger Sudhoff, Department of Otolaryngology Head and Neck Surgery, Bielefeld Academic Teaching Hospital, Teutoburger Str. 50, 33604 Bielefeld, Germany Fax: +44 1223 217559 E-mail: Holger.Sudhoff@rub.de
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Abstract

Objective:

There is growing interest in the presence of Helicobacter pylori in the upper aerodigestive tract, and in the middle ear in patients with otitis media with effusion. Some studies have reported detecting H pylori in the middle ear, although reports to the contrary exist. In this study, we critically evaluate the evidence for the theory that H pylori in the middle ear plays a role in otitis media with effusion.

Material:

We undertook a systematic review of all available studies investigating the presence of H pylori in the middle ear of patients with otitis media with effusion. The current literature was critically analysed using the key words and phrases ‘Helicobacter pylori’ ‘otitis media with effusion’, ‘serous otitis media’, ‘glue ear’ and ‘middle ear’. Six original research papers were identified, studying a total of 203 patients and 27 controls; two of these papers were randomised, controlled studies and four were prospective, cohort studies.

Results:

At present, there is poor evidence for the existence of H pylori-associated otitis media with effusion.

Conclusions:

Further research in the field is needed in order to delineate the presence of H pylori and its role in the pathogenesis of otitis media with effusion.

Keywords

Otitis Media With EffusionGastro-esophageal RefluxHelicobacter PyloriMiddle Ear
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 122 , Issue 9 , September 2008 , pp. 905 - 911
Copyright
Copyright © JLO (1984) Limited 2007

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References

1 Ebmeyer, J, Furukawa, M, Pak, K, Ebmeyer, U, Sudhoff, H, Broide, D et al. Role of mast cells in otitis media. J Allergy Clin Immunol 2005;116:1129–35CrossRefGoogle ScholarPubMed
2 Rovers, MM, Schilder, AG, Zielhuis, GA, Rosenfeld, RM. Otitis media. Lancet 2004;363:465–73CrossRefGoogle ScholarPubMed
3 Agirdir, BV, Bozova, S, Derin, AT, Turhan, M. Chronic otitis media with effusion and Helicobacter pylori. Int J Pediatr Otorhinolaryngol 2006;70:829–34CrossRefGoogle ScholarPubMed
4 Bitar, M, Mahfouz, R, Soweid, A, Racoubian, E, Ghasham, M, Zaatari, G et al. Does Helicobacter pylori colonize the nasopharynx of children and contribute to their middle ear disease? Acta Otolaryngol 2006;126:154–9CrossRefGoogle ScholarPubMed
5 Karlidag, T, Bulut, Y, Keles, E, Kaygusuz, I, Yalcin, S, Ozdarendeli, A et al. Detection of Helicobacter pylori in children with otitis media with effusion: a preliminary report. Laryngoscope 2005;115:1262–5CrossRefGoogle ScholarPubMed
6 Morinaka, S, Tominaga, M, Nakamura, H. Detection of Helicobacter pylori in the middle ear fluid of patients with otitis media with effusion. Otolaryngol Head Neck Surg 2005;133:791–4CrossRefGoogle ScholarPubMed
7 Yilmaz, MD, Aktepe, O, Cetinkol, Y, Altuntas, A. Does Helicobacter pylori have role in development of otitis media with effusion? Int J Pediatr Otorhinolaryngol 2005;69:45–9CrossRefGoogle ScholarPubMed
8 Yilmaz, T, Ceylan, M, Akyon, Y, Ozcakyr, O, Gursel, B. Helicobacter pylori: a possible association with otitis media with effusion. Otolaryngol Head Neck Surg 2006;34:772–7CrossRefGoogle Scholar
9 Schreiber, S, Konradt, M, Groll, C, Scheid, P, Hanauer, G, Werling, HO et al. The spatial orientation of Helicobacter pylori in the gastric mucus. Proc Natl Acad Sci U S A 2004;101:5024–9CrossRefGoogle ScholarPubMed
10 Suerbaum, S, Michetti, P. Helicobacter pylori infection. N Engl J Med 2002;347:175–86CrossRefGoogle ScholarPubMed
11 Nguyen, AM, Engstrand, L, Genta, RM, Graham, DY, el Zaatari, FA Detection of Helicobacter pylori in dental plaque by reverse transcription-polymerase chain reaction. J Clin Microbiol 1993;31:783–7CrossRefGoogle ScholarPubMed
12 Li, C, Musich, PR, Ha, T, Ferguson, DA Jr., Patel, NR, Chi, DS et al. High prevalence of Helicobacter pylori in saliva demonstrated by a novel PCR assay. J Clin Pathol 1995;48:662–6.CrossRefGoogle ScholarPubMed
13 Sudhoff, H, Bücker, R, Groll, C, Shagdarsuren, S, Dazert, S, Schreiber, S. Tracing of gastric reflux into the middle ear in a Mongolian gerbil model. Otol Neurotol 2007;28:124–8CrossRefGoogle Scholar
14 Tasker, A, Dettmar, PW, Panetti, M, Koufman, JA, Birchall, P, Pearson, JP. Is gastric reflux a cause of otitis media with effusion in children? Laryngoscope 2002;112:1930–4CrossRefGoogle ScholarPubMed
15 White, DR, Heavner, SB, Hardy, SM, Prazma, J. Gastroesophageal reflux and eustachian tube dysfunction in an animal model. Laryngoscope 2002;112:955–61CrossRefGoogle ScholarPubMed
16 Post, JC. Direct evidence of bacterial biofilms in otitis media. Laryngoscope 2001;111:2083–94CrossRefGoogle ScholarPubMed
17 Axon, AT. Review article: is Helicobacter pylori transmitted by the gastro-oral route? Aliment Pharmacol Ther 1995;9:585–8CrossRefGoogle ScholarPubMed
18 Clyne, M, Labigne, A, Drumm, B. Helicobacter pylori requires an acidic environment to survive in the presence of urea. Infect Immun 1995;63:1669–73CrossRefGoogle ScholarPubMed
19 Sjöström, JE, Larsson, H. Factors affecting growth and antibiotic susceptibility of Helicobacter pylori: effect of pH and urea on the survival of a wild-type strain and a urease-deficient mutant. J Med Microbiol 1996;44:425–33CrossRefGoogle Scholar
20 Van, AK, van der, EA. Nutrients released by gastric epithelial cells enhance Helicobacter pylori growth. Helicobacter 2004;9:614–21Google Scholar
21 Berloco, P, Cavallini, A, Di, LA, Russo, F. Saliva samples not a reliable tool for diagnosis of Helicobacter pylori infection. Eur J Clin Microbiol Infect Dis 2001;20:68–9CrossRefGoogle Scholar
22 Drumm, B, Perez-Perez, GI, Blaser, MJ, Sherman, PM. Intrafamilial clustering of Helicobacter pylori infection. N Engl J Med 1990;322:359–63CrossRefGoogle ScholarPubMed
23 Rothenbacher, D, Bode, G, Berg, G, Knayer, U, Gonser, T, Adler, G et al. Helicobacter pylori among preschool children and their parents: evidence of parent-child transmission. J Infect Dis 1999;179:398–402CrossRefGoogle ScholarPubMed
24 Luzza, F, Mancuso, M, Imeneo, M, Contaldo, A, Giancotti, L, Pensabene, L et al. Evidence favouring the gastro-oral route in the transmission of Helicobacter pylori infection in children. Eur J Gastroenterol Hepatol 2000;12:623–7CrossRefGoogle ScholarPubMed
25 Parsonnet, J, Shmuely, H, Haggerty, T. Fecal and oral shedding of Helicobacter pylori from healthy infected adults. JAMA 1999;15:2240–5CrossRefGoogle Scholar
26 Laporte, R, Pernes, P, Pronnier, P, Gottrand, F, Vincent, P. Acquisition of Helicobacter pylori infection after outbreaks of gastroenteritis: prospective cohort survey in institutionalised young people. BMJ 2004;24:204–5CrossRefGoogle Scholar
27 Thomas, JE, Gibson, GR, Darboe, MK, Dale, A, Weaver, LT. Isolation of Helicobacter pylori from human faeces. Lancet 1992;340:1194–5CrossRefGoogle ScholarPubMed
28 Klein, PD, Graham, DY, Gaillour, A, Opekun, AR, Smith, EO. Water source as risk factor for Helicobacter pylori infection in Peruvian children. Gastrointestinal Physiology Working Group. Lancet 1991;22:1503–6CrossRefGoogle Scholar
29 Blecker, U, Lanciers, S, Hauser, B, Vandenplas, Y. The prevalence of Helicobacter pylori positivity in a symptom-free population, aged 1 to 40 years. J Clin Epidemiol 1994;47:1095–8CrossRefGoogle Scholar
30 Grimm, W, Fischbach, W. Helicobacter pylori infection in children and juveniles: an epidemiological study on prevalence, socio-economic factors and symptoms [in German]. Dtsch Med Wochenschr 2003;12:1878–83Google Scholar
31 Rowland, M, Daly, L, Vaughan, M, Higgins, A, Bourke, B, Drumm, B. Age-specific incidence of Helicobacter pylori. Gastroenterology 2006;130:65–72CrossRefGoogle ScholarPubMed
32 McNulty, CA, Wise, R. Rapid diagnosis of Campylobacter-associated gastritis. Lancet 1985;8443:1443–4CrossRefGoogle Scholar
33 Tseng, CA, Wang, WM, Wu, DC. Comparison of the clinical feasibility of three rapid urease tests in the diagnosis of Helicobacter pylori infection. Dig Dis Sci 2005;50:449–52CrossRefGoogle ScholarPubMed
34 Madani, S, Rabah, R, Tolia, V. Diagnosis of Helicobacter pylori infection from antral biopsies in pediatric patients: is urease test that reliable? Dig Dis Sci 2000;45:1233–7CrossRefGoogle ScholarPubMed
35 Kisa, O, Albay, A, Mas, MR, Celasun, B, Doganci, L. The evaluation of diagnostic methods for the detection of Helicobacter pylori in gastric biopsy specimens. Diagn Microbiol Infect Dis 2002;43:251–5CrossRefGoogle ScholarPubMed
36 Malfertheiner, P, Megraud, F, O'Morain, C, Bazzoli, F, el-Omar, E, Graham, D et al. Current concepts in the management of Helicobacter pylori infection: the Maastricht III Concensus Report. Gut. 2007;56:772–81CrossRefGoogle Scholar
37 Tokunaga, Y, Shirahase, H, Yamamoto, E, Inao, R, Hamaguchi, S, Kanaji, K et al. Modified rapid urease test for Helicobacter pylori detection in relation to an immunohistochemical stain. J Gastroenterol Hepatol 2000;15:617–21CrossRefGoogle Scholar
38 Nyström, J, Raghavan, S, Svennerholm, AM. Mucosal immune responses are related to reduction of bacterial colonization in the stomach after therapeutic Helicobacter pylori immunization in mice. Microbes Infect 2006;8:442–9CrossRefGoogle ScholarPubMed
39 Queralt, N, Bartolome, R, Araujo, R. Detection of Helicobacter pylori DNA in human faeces and water with different levels of faecal pollution in the north-east of Spain. J Appl Microbiol 2005;98:889–95CrossRefGoogle ScholarPubMed
40 Rees, GL, Freeland, AP. The effect of anaesthesia on tympanograms of children undergoing grommet insertion. Clin Otolaryngol Allied Sci 1992;17:200–2CrossRefGoogle ScholarPubMed