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Current status and clinical association of beta-catenin with juvenile nasopharyngeal angiofibroma

Published online by Cambridge University Press:  30 August 2016

A Mishra ,
V Singh ,
V Verma ,
S Pandey ,
R Trivedi ,
H P Singh ,
S Kumar ,
R C Dwivedi  and
S C Mishra
A Mishra*
Affiliation:
Department of Otorhinolaryngology, King George Medical University, Lucknow, India
V Singh
Affiliation:
Department of Otorhinolaryngology, King George Medical University, Lucknow, India
V Verma
Affiliation:
Department of Otorhinolaryngology, King George Medical University, Lucknow, India
S Pandey
Affiliation:
Department of Biochemistry, King George Medical University, Lucknow, India
R Trivedi
Affiliation:
Department of Endocrinology, Central Drug Research Institute, Lucknow, India
H P Singh
Affiliation:
Department of Otorhinolaryngology, King George Medical University, Lucknow, India
S Kumar
Affiliation:
Department of Otorhinolaryngology, King George Medical University, Lucknow, India
R C Dwivedi
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, Queen Alexandra Hospital, Portsmouth Hospitals NHS Trust, UK
S C Mishra
Affiliation:
Department of Otorhinolaryngology, Nepalgunj Medical College, Kohlpur, Nepal
*
Address for correspondence: Dr Anupam Mishra, Department of Otorhinolaryngology, King George Medical University, Lucknow, India E-mail: amishra_ent@yahoo.com
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Abstract

Objective:

A possible role of the APC/beta-catenin pathway in the pathogenesis of sporadic juvenile nasopharyngeal angiofibroma has been suggested. This paper presents its current status and clinical association in our patients.

Method:

A prospective observational study was conducted at King George Medical University and Central Drug Research Institute, in Lucknow, India. Western blot analysis was undertaken in 16 cases to examine beta-catenin expression. The clinical details were recorded along with follow up observations, to determine associations.

Results:

Up-regulation of beta-catenin expression was seen in 69 per cent of cases. The clinical variables did not reveal significant differences between patients with extremes of expression (extreme under- vs over-expression). However, absent expression was shown exclusively in young adults aged over 18 years, while enhanced expression was associated with an altered facial profile.

Conclusion:

Although a beta-catenin association was seen in a subset of our sporadic juvenile nasopharyngeal angiofibroma cases, its expression was not homogeneous. This is in contrast to the Western literature that suggests a universal (homogenous) enhanced expression in the majority. Hence, further research is required to better define its molecular cascade.

Keywords

Juvenile Nasopharyngeal AngiofibromaBeta-Catenin
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 10 , October 2016 , pp. 907 - 913
Copyright
Copyright © JLO (1984) Limited 2016 

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