Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-10T15:11:28.606Z Has data issue: false hasContentIssue false
  • English
  • Français

Cyclin Dl expression as a prognostic factor in advanced hypopharyngeal carcinoma

Published online by Cambridge University Press:  29 June 2007

Goshi Nishimura ,
Mamoru Tsukuda ,
Li-Xin Zhou ,
Shigeru Furukawa  and
Yuh Baba
Goshi Nishimura*
Affiliation:
Department of Otorhinolaryngology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
Mamoru Tsukuda
Affiliation:
Department of Otorhinolaryngology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
Li-Xin Zhou
Affiliation:
Department of Otorhinolaryngology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
Shigeru Furukawa
Affiliation:
Department of Otorhinolaryngology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
Yuh Baba
Affiliation:
Department of Otorhinolaryngology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
*
AddressAddress for correspondence: Goshi Nishimura, M.D., Department of Otorhinolaryngology, Yokohama City University School of Medicine, 3–9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, Japan236-0004.
Get access Rights & Permissions [Opens in a new window]

Abstract

Hypopharyngeal carcinoma (HPC) has a poor prognosis. We investigated the expression of cyclin D1 in 34 advanced HPCs, and the value of cyclin D1 expression was evaluated as a predictive marker in terms of the prognosis of HPC, compared with other clinical factors. Using immunohistochemical staining, 20 of 34 patients showed positive immunoreactivity for cyclin D1. The statistical trend of the survival rate was lower in the cyclin Di-positive patients than in the cyclin D-negative ones (p = 0.0805). The predictive factors for the survival rate were effectiveness of neo-adjuvant chemotherapy (F = 8.698) (p = 0.0066), cyclin D1 expression (F = 6.244) (p = 0.0191) and N classification (F = 5.037) (p = 0.0335). The cyclin D1-positive patients had approximately four-fold higher mortality than the cyclin D1-negative ones. These data indicate that the expression of cyclin D1 in advanced patients with hypopharyngeal carcinoma is a useful marker for prognosis.

Keywords

HypopharynxCarcinomaImmunochemistryPrognosis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 6 , June 1998 , pp. 552 - 555
Copyright
Copyright © JLO (1984) Limited 1998

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Akervall, J. A., Michalides, R. J. A. M., Mineta, H., Balm, A., Borg, A., Dictor, M. R., Jin, Y., Loftus, B., Mertens, F., Wennerberg, J. P. (1997) Amplification of cyclin Dl in squamous cell carcinoma of head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression. Cancer 79: 380–389.3.0.CO;2-W>CrossRefGoogle Scholar
Bartkova, J., Lukas, J., Muller, H., Strauss, M., Gusterson, B., Bartek, J. (1995) Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer. Cancer Research 55: 949–956.Google ScholarPubMed
Bennett, M., Wilson, G., Dische, S., Saunders, M., Martindale, C., Robinson, B., O'Halloran, A., Leslie, M., Laing, J. (1992) Tumour proliferation assessed by combined histological and flow cytometrical analysis: implications for therapy in squamous cell carcinoma in head and neck. British Journal of Cancer 65: 870–878.CrossRefGoogle ScholarPubMed
Callender, T., El-Naggar, A. K., Lee, M. S., Frankenthaler, R., Luna, M. A., Batsakis, J. G. (1994) PRAD-1 (CCND1)/ Cyclin D1 oncogene amplification in primary head and neck squamous cell carcinoma. Cancer 74: 152–158.3.0.CO;2-K>CrossRefGoogle ScholarPubMed
Corvo, R., Giaretti, W., Sanguineti, G., Geido, E., Orecchia, R., Guenzi, M., Margarino, G., Bacigalupo, A., Garaventa, G., Barbieri, M., Vitale, V. (1995) In vivo cell kinetics in head and neck squamous cell carcinomas predicts local control and helps guide radiotherapy regimen. Journal of Clinical Oncology 13: 1843–1850.CrossRefGoogle ScholarPubMed
Fantl, V., Richards, M. A., Smith, R., Lammie, G. A., Johnstone, G., Allen, D., Gregory, W., Peters, G., Dickson, C., Barnes, D. M. (1990) Gene amplification on chromosome band 11q13 and oestrogen receptor status in breast cancer. European Journal of Cancer 26: 423–429.CrossRefGoogle ScholarPubMed
Foster, G., Cooke, T., Cooke, L., Stanton, P., Bowie, G., Stell, P. (1992) Tumour growth rates in squamous carcinoma of head and neck measured by in vivo bromodeoxyuridine incorporation and flow cytometry. British Journal of Cancer 65: 698–702.CrossRefGoogle Scholar
Inaba, T., Matsushime, H., Valentine, M., Roussel, M. F., Sherry, C. J., Look, A. T. (1992) Genomic organization, chromosomal localization and independent expression of human cyclin D genes. Genomics 13: 565–574.CrossRefGoogle ScholarPubMed
Kotelnikov, V. M., Coon, J., Haleem, A., Taylor, S., Hutchinson, J., Panje, W., Caldarelli, D., Preisler, H. D. (1995) Cell kinetics of head and neck cancers. Clinical Cancer Research 1: 527–537.Google ScholarPubMed
Matsuda, M., Hirakawa, N., Nakashima, T., Kuratomi, Y., Komiyama, S. (1996) Cyclin D1 overexpression in primary hypopharyngeal carcinomas. Cancer 78: 390–395.3.0.CO;2-O>CrossRefGoogle Scholar
Matsushime, H., Roussel, M. F., Ashmun, R. A., Sherr, C. J. (1992) Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 71: 323–334.CrossRefGoogle Scholar
Meyerson, M., Harlow, E. (1994) Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Molecular and Cellular Biology 14: 2077–2080.Google ScholarPubMed
Michalides, R., Veelen, N., Hart, A., Loftus, B., Wientjens, E., Balm, A. (1995) Overexpression of cyclin D1 correlates with recurrence in group of forty-seven operable squamous cell carcinomas of head and neck. Cancer Research 55: 975–978.Google ScholarPubMed
Motokura, T., Bloom, T., Kim, H. G., Juppner, H., Ruderman, J. V., Kronenberg, H. M., Arnold, A. (1991) A novel cyclin encoded by a bcl 1-linked candidate oncogene. Nature 350: 512–515.CrossRefGoogle Scholar
Muller, D., Millon, R., Lidereau, R., Engelmann, A., Bronner, G., Flesch, H., Eber, M., Methlia, G., Abecassis, J. (1994) Frequent amplification of 11q13 DNA markers is associated with lymph node involvement in human head and neck squamous cell carcinomas. European Journal of Cancer 2: 113–120.CrossRefGoogle Scholar
Naitoh, H., Shibata, J., Kawaguchi, A., Kodama, M., Hattori, T. (1995) Overexpression and localization of cyclin Dl mRNA and antigen in esophageal carcinomas. American Journal of Pathology 146: 1161–1169.Google Scholar
Nishida, N., Fukuda, Y., Komeda, T., Kita, R., Sando, T., Furukawa, M., Amenomori, M., Shibagaki, I., Nakao, K., Ikenaga, M., Ishizaki, K. (1994) Amplification and overexpression of cyclin D1 gene in aggressive human hepatocellular carcinoma. Cancer Research 54: 3107–3110.Google ScholarPubMed
Rosenberg, C. L., Wong, E., Petty, E. M., Bale, A. E., Tsujimoto, Y., Harris, N. L., Arnold, A. (1991) PRAD-1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma. Proceedings of the National A cademy of Science of the United States of America 88: 9638–9642.CrossRefGoogle Scholar
Schuuring, E., Verhoeven, E., Mooi, W. J., Michalides, R. J. A. M. (1992) Identification and cloning of two overexpressed genes, U21B31/PRAD 1 and EMS 1, within the amplified chromosome 11q13 region in human carcinomas. Oncogene 7: 355–361.Google Scholar
Tomasino, R. M., Daniele, E., Bazan, V., Morello, V., Tralongo, V., Nuara, R., Nagar, C., Salvato, M., Ingria, F., Restivo, S., Dardanoni, G., Vecchione, A., Russo, A. (1995) Prognostic significance of cell kinetics in laryngeal squamous cell carcinoma: clinicopathological associations. Cancer Research 55: 6130–6108.Google ScholarPubMed
Tsuda, T., Tahara, E., Kajiyama, G., Sakamoto, H., Terada, M., Sugimura, T. (1989) High incidence of coamplification of hst-1 and int-2 genes in human esophageal carcinomas. Cancer Research 49: 5505–5508.Google ScholarPubMed
Williams, M. E., Gaffey, M. J., Weiss, L. M., Wilczynski, S. P., Schuuring, E., Lavine, P. A. (1993) Chromosome 11q13 amplification in head and neck squamous cell carcinoma. Archives of Otolaryngology – Head and Neck Surgery 119: 1238–1243.CrossRefGoogle ScholarPubMed
Xiong, Y., Manninger, J., Beach, D., Ward, D. C. (1992a) Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyckins. Genomics 13; 575–584.CrossRefGoogle Scholar
Xiong, Y., Zhang, H., Beach, D. (1992b) D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell 71: 505–514.CrossRefGoogle ScholarPubMed