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Diagnostic importance of the nucleolar organizer regions in Wegener's granulomatosis

Published online by Cambridge University Press:  29 June 2007

Wen L. Yue ,
Zheng Z. Ma  and
Zhi H. Sun
Wen L. Yue*
Affiliation:
Department of Otolaryngology, Pingdingshan People's HospitalNo. 1, Henan, People's Republic of China.
Zheng Z. Ma
Affiliation:
Department of Otolaryngology, Pingdingshan People's HospitalNo. 1, Henan, People's Republic of China.
Zhi H. Sun
Affiliation:
Department of Otolaryngology, Pingdingshan People's HospitalNo. 1, Henan, People's Republic of China.
*
Address for correspondence: Wen L. Yue, M.D., Department of Otolaryngology, Pingdingshan People's Hospital No. 1, Henan 467000, People's Republic of China.
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Abstract

The number and distribution pattern of silver staining nucleolar organizer regions (AgNORs) were thought to reflect the cellular proliferative activity and the malignancy of tumours. Using a silver-staining method, the variations of AgNORs have been studied in patients with atypical inflammatory lesion (n = 5), malignant reticulosis (n = 5) and Wegener's granulomatosis (n = 6). Our results reveal that there was a statistically significant difference (p<0.01), highly suggestive of a difference in AgNOR counts between the atypical inflammatory lesion and Wegener's granulomatosis, with the Wegener's granulomatosis specimens having the higher irregular AgNORs, but the difference between Wegener's granulomatosis and malignant reticulosis is probably not clinically important. It is concluded that AgNORs may be useful in differentiating Wegener's granulomatosis from an atypical inflammatory lesion, and the simplified counting technique is adequate for the purpose.

Keywords

Wegener's granulomatosisNucleolus organizer regionSilver staining
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 111 , Issue 9 , September 1997 , pp. 825 - 828
Copyright
Copyright © JLO (1984) Limited 1997

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