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The diagnostic value of positron emission tomography (PET) with radiolabelled fluorodeoxyglucose (18F-FDG) in head and neck cancer

Published online by Cambridge University Press:  29 June 2007

N. J. Slevin ,
C. D. Collins ,
D. L. Hastings ,
M. L. Waller ,
R. J. Johnson ,
R. A. Cowan ,
A. R. Birzgalis ,
W. T. Farrington  and
R. Swindell
N. J. Slevin*
Affiliation:
Department of Clinical Oncology, Christie Hospital NHS Trust, Manchester, UK.
C. D. Collins
Affiliation:
Department of Diagnostic Radiology, Christie Hospital NHS Trust, Manchester, UK.
D. L. Hastings
Affiliation:
Department of Medical Physics, Christie Hospital NHS Trust, Manchester, UK.
M. L. Waller
Affiliation:
Department of Medical Physics, Christie Hospital NHS Trust, Manchester, UK.
R. J. Johnson
Affiliation:
Department of Diagnostic Radiology, Christie Hospital NHS Trust, Manchester, UK.
R. A. Cowan
Affiliation:
Department of Clinical Oncology, Christie Hospital NHS Trust, Manchester, UK.
A. R. Birzgalis
Affiliation:
Department of Surgery, Christie Hospital NHS Trust, Manchester, UK.
W. T. Farrington
Affiliation:
Department of Surgery, Christie Hospital NHS Trust, Manchester, UK.
R. Swindell
Affiliation:
Department of Medical Statistics, Christie Hospital NHS Trust, Manchester, UK.
*
Address for correspondence: Dr N. J. Slevin, F.R.C.R., F.R.C.R., Department of Clinical Oncology, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX.
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Abstract

Positron emission tomography (PET) scanning has recently been introduced into clinical practice but its usefulness in the management of head and neck cancer is not well defined. The aim of this prospective preliminary study was to examine the clinical value of fluorodeoxyglucose (FDG) – PET in patients with head and neck cancer treated by radiotherapy with surgery in reserve by (i) relating quantitative uptake of isotope to tumour type and histological grade and (ii) comparing the imaging findings of PET and magnetic resonance imaging (MRI) in post-radiotherapy assessment of tumour response. Twenty-one patients had pre-treatment PET and MRI scans and these were repeated four and eight months after treatment if there was no clinical relapse. Pre-treatment uptake of FDG using tumour to cerebellar ratio parameters was significantly related to the histological grade of squamous cancer (p = 0.04) but not to tumour type. Discordance of post-treatment PET/MRI findings in one case indicates a possible role for PET in the early detection of tumour recurrence. Other potential uses of PET scanning in the management of head and neck cancer are discussed.

Keywords

Tomography, emission-computedHead and neck neoplasms
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 113 , Issue 6 , June 1999 , pp. 548 - 554
Copyright
Copyright © JLO (1984) Limited 1999

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References

Anzai, Y., Carroll, W. R., Quint, D. J., Bradford, C. R., Minoshima, S., Wolf, G. T., Wahl, R. L. (1996) Recurrence of head and neck after surgery or irradiation: prospective comparison of 2-deoxy-2-[F-18] fluoro-D-glucose PET and MR imaging diagnoses. Radiology 200(1): 135–141.CrossRefGoogle ScholarPubMed
Bailet, J. W., Sercarz, J. A., Abemayor, E., Anzai, Y., Lufkin, R. B., Hoh, C. K. (1995) The use of positron emission tomography for early detection of recurrent head and neck squamous cell carcinoma in postradiotherapy patients. Laryngoscope 105(2): 135–139.Google Scholar
Braams, J. W., Pruim, J., Freling, N. J., Nikkels, P. G., Roodenburg, J. L., Boering, G., Vaalburg, W., Vermey, A. (1995) Detection of lymph node metastases of squamouscell cancer of the head and neck with FDG-PET and MRI. Journal of Nuclear Medicine 36(2): 211–216.Google ScholarPubMed
Braams, J. W., Pruim, J., Kole, A. C., Nikkels, P. G., Vaalburg, W., Vermey, A., Roodenburg, J. L. (1997) Detection of unknown primary head and neck tumours by positron emission tomography. International Journal of Oral Maxillofacial Surgery 26(2): 112–115.Google Scholar
Chaiken, L., Rege, S., Hoh, M. D., Choi, Y., Jabour, B., Juillard, G., Hawkins, R., Parker, R. (1993) Positron emission tomography with flurordeoxyclucose to evaluate tumour response and control after radiation therapy. International Journalof Radiation Oncology Biology and Physics 27: 455–464.Google Scholar
DiChiro, G., DeLaPaz, R. L., Brooks, R. A. (1982) Glucose utilization of cerebral gliomas measured by (18F) Fluorodeoxy glucose and positron emission tomography. Neurology 32: 1323–1329.Google Scholar
Greven, M. K., Williams, D. W. III, Keyes, J. W. Jr., McGuirt, W. F., Watson, N. E. Jr., Randall, M. E., Raben, M., Geisinger, K. R., Cappellari, J. O. (1994) Positron emission tomography of patients with head and neck carcinoma before and after high dose irradiation. Cancer 74: 1355–1359.3.0.CO;2-I>CrossRefGoogle ScholarPubMed
Haberkorn, U., Strauss, L. G., Dimitrakopoulou, A., Seiffert, E., Oberdorfer, F., Ziegler, S., Reisser, C., Doll, J., Helus, F., van Kaick, G. (1993) Fluorodeoxyglucose imaging of advanced head and neck cancer after chemotherapy. Journal of Nuclear Medicine 34: 12–17.Google ScholarPubMed
Hastings, D. L., Moore, J. V., Waller, M. L., Acton, P. D., Dodd, N. J., Hand, J. C., Nuttall, P. M., Jeavons, A. P. (1996) High resolution PET imaging of tumour using 18FDG in Quantitative Imaging in Oncology. Proceedings of the 19th LH Gray Conference (Faulkner, K., Carey, B., Crellin, A. eds.) British Journal of Radiology London.Google Scholar
Laubenbacher, C., Saumweber, D., Wagner-Manslau, C., Kau, R. J., Herz, M., Avril, N., Siegler, S., Kruschke, C., Arnold, W., Schwaiger, M. (1995) Comparison of fluorine-18-fluorodoxyglucose PET, MRI and endoscopy for staging head and neck squamous-cell carcinomas. Journal of Nuclear Medicine 36(10): 1747–1757.Google ScholarPubMed
Leskinnen-Kallio, S., Ruotsalainen, U., Nagren, K., Teras, M., Joensuu, H. (1991) Uptake of carbon-11-methionine and FDG in non Hodgkins lymphoma: a PET study. Journal of Nuclear Medicine 32: 1211–1218.Google Scholar
McGuirt, W. F., Williams, D. W. III, JrKeyes, J. W., Greven, K. M., JrWatson, N. E., Geisinger, K. R., Cappellari, J. O. (1995) A comparative diagnostic study of head and neck nodal metastases using positron emission tomography. Laryngoscope 105(4 Pt 1): 373–375.Google Scholar
Minn, H., Joensuu, H., Ahonen, A. (1988) Fluorodeoxyglucose imaging: a comparison with DNA flow cytometry in head and neck tumours. Cancer 61: 1776–1781.3.0.CO;2-7>CrossRefGoogle Scholar
Moore, J. V., Hastings, D. L., Waller, M. L., Zhao, S., Acton, P. D., Jeavons, A. P., Dodd, N. J. F. (1998) Feasibility of imaging photodynamic injury to tumours by high resolution positron emission tomography: pre-clinical studies. European Journal Nuclear Medicine 25: 1248–1254.CrossRefGoogle Scholar
Mukherji, S. K., Drane, W. E., Mancuso, A. A., Parsons, J. T., Mendenhall, W. M., Stringer, S. (1996) Occult primary tumours of the head and neck: detection with 2-[F-18] fluoro-2-doxy-D-glucose SPECT. Radiology 199(3): 761–766.Google Scholar
Price, P., Jones, T., on behalf of the EC PET Oncology Concerted Action and the EORTC PET Study Group (1995) Can positron emission tomography (PET) be used to detect subclinical response to cancer therapy? European Journal of Cancer 31A(12): 1924–1927.CrossRefGoogle ScholarPubMed
Rege, S., Maass, A., Chaiken, L., Hoh, C. K., Choi, Y., Lufkin, R., Anzai, Y., Juillard, G., Maddahi, J., Phelps, M. E. (1994) Use of positron emission tomography with fluorodeoxyglucose in patients with extracranial head and neck cancers. Cancer 73: 3047–3058.Google Scholar
Siegel, S. (1956) Non-Parametric Statistics for the Behavioural Sciences Chapter 8. McGraw-Hill, New York, Toronto, London. pp 184–193.Google Scholar
Townsend, D. (1987) High density avalanche chamber (HIDAC) positron camera. Journal of Nuclear Medicine 28: 1554–1562.Google Scholar
Wong, W. L., Chevretton, E. B., McGurk, M., Hussain, K., Davis, J., Beaney, R., Baddeley, H., Tierney, P., Maisey, M. (1997) A prospective study of PET-FDG imaging for the assessment of head and neck squamous cell carcinoma. Clinical Otolaryngology 22: 209–214.Google Scholar