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Distribution and significance of endothelin 1 in guinea pig cochlear lateral wall

Published online by Cambridge University Press:  26 February 2007

D-Y Xu ,
Y-D Tang ,
S-X Liu  and
J Liu
D-Y Xu
Affiliation:
Department of Otorhinolaryngology, West China Hospital of Sichuan University, Chengdu, China
Y-D Tang*
Affiliation:
Department of Otorhinolaryngology, West China Hospital of Sichuan University, Chengdu, China
S-X Liu
Affiliation:
Department of Otorhinolaryngology, West China Hospital of Sichuan University, Chengdu, China
J Liu
Affiliation:
Neural Science Center, West China Hospital of Sichuan University, Chengdu, China.
*
Address for correspondence: Yue-Di Tang, Department of Otorhinolaryngology, West China Hospital of Sichuan University, Chengdu, China 610041. E-mail: tangyd@hotmail.com
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Abstract

Endothelin 1 is a vasoconstrictive peptide with many biological functions. To investigate the distribution of endothelin 1 in guinea pig cochlear lateral wall and the significance of endothelin 1 in maintaining cochlear homeostasis, the immunohistochemistry avidin biotin complex method was applied by using rabbit anti-endothelin 1 polyclonal antibody as primary antibody. Endothelin-1-like activities were detected in the marginal cells, spiral prominence epithelial cells, outer sulcus cells, stria vascularis capillaries, basal cells and spiral ligament fibrocytes.

These results suggest that endothelin 1 may play an important role in maintaining cochlear homeostasis.

Keywords

Endothelin 1CochleaGuinea PigImmunohistochemistry
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 121 , Issue 8 , August 2007 , pp. 721 - 724
Copyright
Copyright © JLO (1984) Limited 2007

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