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Effect of central compartment neck dissection on hypocalcaemia incidence after total thyroidectomy for carcinoma

Published online by Cambridge University Press:  25 November 2010

I Mitra ,
J R Nichani ,
B Yap  and
J J Homer
I Mitra
Affiliation:
Department of Otolaryngology–Head and Neck Surgery, Manchester Royal Infirmary, Manchester, UK
J R Nichani
Affiliation:
Department of Otolaryngology–Head and Neck Surgery, Manchester Royal Infirmary, Manchester, UK
B Yap
Affiliation:
Department of Oncology, Christie Hospital, Manchester, UK
J J Homer*
Affiliation:
Department of Otolaryngology–Head and Neck Surgery, Manchester Royal Infirmary, Manchester, UK School of Cancer and Imaging, University of Manchester, UK
*
Address for correspondence: Mr Jarrod J Homer, Consultant Head and Neck Surgeon, Department of Otolaryngology–Head and Neck Surgery, Manchester Royal Infirmary, Oxford Rd, Manchester M13 9WL, UK Fax: 44 (0)161 276 5003 E-mail: jarrod.homer@manchester.ac.uk
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Abstract

Introduction:

Central compartment neck dissection is increasingly performed as part of surgical management of differentiated thyroid carcinoma. However, elective central neck dissection remains controversial due to complications and lack of evidence of survival benefit.

Objective:

To investigate and compare rates of transient and permanent hypocalcaemia following total thyroidectomy alone, compared with total thyroidectomy with central neck dissection, for differentiated thyroid carcinoma.

Methods:

Retrospective study of 127 consecutive patients referred with differentiated thyroid carcinoma, 2004–2006; 78 patients had undergone total thyroidectomy (group one) and 49 total thyroidectomy with central compartment node dissection (group two). Surgery was performed in various hospitals by both otolaryngologists and endocrine surgeons.

Results:

In groups one and two, the incidence of transient hypocalcaemia was 18 per cent (14/78) and 51 per cent (25/49) (p < 0.001), and the incidence of permanent hypocalcaemia 1 per cent (one of 77) and 12 per cent (six of 49) (p < 0.01), respectively. Most patients undergoing central neck dissection had evidence of pathological level six lymphadenopathy (29/49).

Conclusion:

Total thyroidectomy combined with central neck dissection for the treatment of differentiated thyroid carcinoma is more likely to result in transient (51 per cent) and permanent (12 per cent) hypocalcaemia. Elective neck dissection should be performed selectively, with a high expectation of post-operative hypocalcaemia.

Keywords

Thyroid CarcinomaNeck DissectionSurgeryHypocalcemia
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 5 , May 2011 , pp. 497 - 501
Copyright
Copyright © JLO (1984) Limited 2010

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Footnotes

Presented at the British Academic Conference in Otolaryngology, 8–10 July 2009, Liverpool, UK

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