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Efficacy of intratympanic methylprednisolone acetate in treatment of drill-induced sensorineural hearing loss in guinea pigs

Published online by Cambridge University Press:  08 March 2006

Diaa M El-Hennawi ,
Mohamed H Badr El-Deen ,
Ashraf S Abou-Halawa ,
Hani S Nadeem  and
Mohamed R Ahmed
Diaa M El-Hennawi
Affiliation:
Otorhinolaryngology Department, Suez Canal University, Ismailia, Egypt
Mohamed H Badr El-Deen
Affiliation:
Otorhinolaryngology Department, Suez Canal University, Ismailia, Egypt
Ashraf S Abou-Halawa
Affiliation:
Otorhinolaryngology Department, Suez Canal University, Ismailia, Egypt
Hani S Nadeem
Affiliation:
Ain Shams University, Anatomy Department, Cairo, Egypt
Mohamed R Ahmed
Affiliation:
Ain Shams University, Anatomy Department, Cairo, Egypt
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Abstract

Intratympanic steroids offer direct access to the inner ear with high concentration and without systemic effects. In this study, the efficacy of intratympanic methylprednisolone acetate (IT-MPA) was evaluated in a guinea-pig model of drill-induced inner ear trauma.

Twenty-five guinea pigs were divided into a control group to document the baseline distortion product otoacoustic emissions (DPOAEs) and the normal scanning electron microscopic (SEM) morphology of the inner ear. The animals in the study group were subdivided into a steroid-only group (S), a trauma-only group(T), a trauma-plus-time group (TT), and a trauma-plus-steroid (TS) group.

IT-MPA was found to have no damaging effect on the inner ear. Twelve days after trauma, there was spontaneous although incomplete recovery of the DPOAEs amplitudes and SEM morphology with scar tissue replacing lost outer hair cells. Statistically higher DPOAEs amplitudes (p < 0.05) were recorded in the TS group that had nearly normal SEM morphology compared to the TT group. The authors conclude that IT-MPA significantly improves drill-induced sensorineural hearing loss and inner ear morphological changes in guinea pigs.

Keywords

Hearing Loss, SensorineuralHearing Loss, Noise-inducedGuinea PigsMethylprednisoloneMicroscopy, Electron, Scanning TransmissionOtoacoustic Emissions, Spontaneous
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 119 , Issue 1 , January 2005 , pp. 2 - 7
Copyright
© 2005 Royal Society of Medicine Press

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