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ENT manifestations in Iranian patients with primary antibody deficiencies

Published online by Cambridge University Press:  07 April 2017

A Aghamohammadi ,
K Moazzami ,
N Rezaei ,
A Karimi ,
M Movahedi ,
M Gharagozlou ,
S Abdollahzade ,
N Pouladi ,
A Kouhi  and
M Moin
A Aghamohammadi*
Affiliation:
Department of Allergy and Clinical Immunology, Children's Medical Center, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
K Moazzami
Affiliation:
Department of Allergy and Clinical Immunology, Children's Medical Center, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
N Rezaei
Affiliation:
Department of Allergy and Clinical Immunology, Children's Medical Center, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
A Karimi
Affiliation:
Department of Ear, Nose, and Throat, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
M Movahedi
Affiliation:
Department of Allergy and Clinical Immunology, Children's Medical Center, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
M Gharagozlou
Affiliation:
Department of Allergy and Clinical Immunology, Children's Medical Center, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
S Abdollahzade
Affiliation:
Department of Allergy and Clinical Immunology, Children's Medical Center, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
N Pouladi
Affiliation:
Department of Allergy and Clinical Immunology, Children's Medical Center, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
A Kouhi
Affiliation:
Department of Allergy and Clinical Immunology, Children's Medical Center, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
M Moin
Affiliation:
Department of Allergy and Clinical Immunology, Children's Medical Center, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
*
Address for correspondence: Asghar Aghamohammadi, Children's Medical Center Hospital, No 62, Dr Gharib St, Keshavarz Blvd, PO Box: 14185-863, Tehran 14194, Iran. Fax: +98 21 6642 89 95 E-mail: aghamohammadi@sina.tums.ac.ir
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Abstract

Objective:

One hundred and nine patients with primary antibody deficiencies were selected in order to determine the frequency of ENT complications.

Method:

Demographic information and ENT medical histories were collected for each patient. Duration of study for each patient was divided into two periods of before diagnosis and after diagnosis and the initiation of treatment.

Results:

Eighty-two of 109 patients (75.2 per cent) experienced ENT infections during the course of the disease (63: otitis media, 75: sinusitis and nine: mastoiditis). At the time of diagnosis, 52 (47.7 per cent) out of 109 patients presented with an ENT symptom. The frequencies of episodes were 27 for sinusitis and 25 for otitis media (one complicated with mastoiditis). After immunoglobulin replacement therapy the incidence of otitis media was reduced from 1.75 before treatment to 0.39 after treatment per patient per year (p = 0.008). The incidence of sinusitis also significantly decreased from 2.38 to 0.78 (p value = 0.011).

Conclusion:

ENT infections are common medical problems in primary antibody deficiency patients. Persistent and recurrent ENT infections should be suspected as originating from a possible underlying immunodeficiency.

Keywords

Antibody Deficiency SyndromesOtolaryngologySinusitisOtitis MediaIran
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 122 , Issue 4 , April 2008 , pp. 409 - 413
Copyright
Copyright © JLO (1984) Limited 2007

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