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Genetics of otosclerosis

Published online by Cambridge University Press:  29 June 2007

R. Sabitha ,
Ravi Ramalingam ,
K. K. Ramalingam ,
T. A. Sivakumaran  and
A. Ramesh
R. Sabitha
Affiliation:
Department of Genetics, Dr ALM PGIBMS, Taramani, Madras.
Ravi Ramalingam
Affiliation:
K. K. R. ENT Hospital and Research Institute, 827, Poonamallee High Road, Kilpauk, Madras 600 010, India.
K. K. Ramalingam
Affiliation:
K. K. R. ENT Hospital and Research Institute, 827, Poonamallee High Road, Kilpauk, Madras 600 010, India.
T. A. Sivakumaran
Affiliation:
Department of Genetics, Dr ALM PGIBMS, Taramani, Madras.
A. Ramesh*
Affiliation:
Department of Genetics, Dr ALM PGIBMS, Taramani, Madras.
*
Address for correspondence: Dr A. Ramesh, Department of GeneticsDr ALMPGIBMS, Taramani, Madras 600 113, India. Fax: 91-044-4926709
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Abstract

Otosclerosis is an early-middle adult life genetic disease affecting bone remodelling in the ear. Current knowledge of otosclerosis as an inherited disease dates to the mid-19th century, and we report here an attempt to understand the genetics of otosclerosis and detect its heterogeneity. The analysis was conducted on 151 otosclerotic families. The results of our study indicate that while heredity plays an important role in the manifestation of the disease a substantial portion of otosclerotic cases could arise due to non-genetic causes.

Keywords

Otoscierosisgenetics
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 111 , Issue 2 , February 1997 , pp. 109 - 112
Copyright
Copyright © JLO (1984) Limited 1997

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Footnotes

This work was presented at the Seminar on Genetic Epidemiology and XX Annual Conference of Indian Society of Human Genetics held December 11–13, 1994, at the Department of Genetics, Osmania University, Hyderabad – 7.

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