Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-14T05:55:28.076Z Has data issue: false hasContentIssue false
  • English
  • Français

Gentamicin administration via peritoneal dialysis fluid: the risk of ototoxicity

Published online by Cambridge University Press:  29 June 2007

B. S. Gendeh ,
H. Said ,
A. G. Gibb ,
N. S. Aziz  and
Z. M. Zahir
B. S. Gendeh
Affiliation:
Kuala Lumpur, Malaysia
H. Said*
Affiliation:
Kuala Lumpur, Malaysia
A. G. Gibb
Affiliation:
Kuala Lumpur, Malaysia
N. S. Aziz
Affiliation:
Kuala Lumpur, Malaysia
Z. M. Zahir
Affiliation:
Kuala Lumpur, Malaysia
*
H. Said, F.R.C.S.Ed., F.R.C.S. Glas., Associate Professor and Head of ENT Department, Faculty of Medicine, National University of Malaysia (U.K.M.), Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur.
Get access Rights & Permissions [Opens in a new window]

Abstract

In a prospective study on 47 patients, 16 mg of gentamicin per two litres dialysate was administered intraperitoneally at every cycle of intermittent peritoneal dialysis, carried out over the course of several days. Serum gentamicin sampling, pure tone audiometry and caloric tests were performed before and during the treatment. The gentamicin levels reached at the end of the thirtieth cycle were observed to be low. In view of this, the risk of acute ototoxicity was considered to be minimal. This was confirmed by the absence of clinical audiometric or vestibulometric evidence of toxicity.

Keywords

OtoxicityGentamicinDialysisperitoneal
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 105 , Issue 12 , December 1991 , pp. 999 - 1001
Copyright
Copyright © JLO (1984) Limited 1991

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Paper presented at Fourth ASEAN, Otorhinolaryngological and Head and Neck Congress Organised by the Academy of Medicine, Singapore, April, 1989.

References

Gary, N. E. (1972) Peritoneal clearance and removal of gentamicin. Journal of Infectious Disease, 124 Supplement: 96–97.CrossRefGoogle Scholar
Gilman, G., Goodman, L. S., Rall, T. W., Murad, F. (1985) The Pharmacological Basis of Therapeutics, (seventh edition). Macmillan Publishing Co., New York, p. 1161–1162.Google Scholar
Hewitt, W. L. (1973) Reflections of the clinical pharmacology of gentamicin. Acta Pathologica et Microbiologica Scandinavica, Supplement. 241: 151–156.Google Scholar
Mohan, W. A., Ecer, J. I., Fenton, S. S., Coltron, D. C. (1973) Studies on gentamicin clearance during peritoneal and hemodialysis. Clinical Research, 21: 1018–1019.Google Scholar
Selvador, P., Christina, C. (1981) Pharmacokinetics of gentamicin in patients undergoing continuous ambulatory peritoneal dialysis. Journal of Antimicrobial Chemotherapy, 19 (4): 605–607.Google Scholar
Smithivas, T., Hyams, P. J., Matalon, P., Simberkoff, M. S., Rahal, J. J. (1971) The use of gentamicin in peritoneal dialysis. Journal of Infectious Diseases, Supplement: 77–83.CrossRefGoogle ScholarPubMed