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Helicobacter pylori in the tonsillar tissue: a possible association with chronic tonsillitis and laryngopharyngeal reflux

Published online by Cambridge University Press:  20 March 2017

N Siupsinskiene ,
I Katutiene ,
V Jonikiene ,
D Janciauskas  and
S Vaitkus
N Siupsinskiene*
Affiliation:
Faculty of Health Sciences, Klaipeda University, Kaunas, Lithuania Department of Otolaryngology, Academy of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania
I Katutiene
Affiliation:
ENT department, Klaipeda Republic Hospital, Kaunas, Lithuania
V Jonikiene
Affiliation:
ENT department, Klaipeda Republic Hospital, Kaunas, Lithuania
D Janciauskas
Affiliation:
Department of Pathologic Anatomy, Academy of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania
S Vaitkus
Affiliation:
Department of Otolaryngology, Academy of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania
*
Address for correspondence: Dr Nora Siupsinskiene, Department of Otolaryngology, Academy of Medicine, Lithuanian University of Health Sciences, Eiveniu 2, Kaunas LT-50009, Lithuania Fax: +370 37 326862 E-mail: norai_s@yahoo.com
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Abstract

Objective:

To identify Helicobacter pylori infection in tonsillar tissue samples from patients undergoing tonsillectomy for chronic tonsillitis versus tonsillar hypertrophy, and to assess the possible relationships between H pylori and patients’ sociodemographic data and laryngopharyngeal reflux.

Methods:

In this prospective study, 97 patients who underwent tonsillectomy were divided into the following 2 groups: patients with chronic tonsillitis (n = 62) and patients with tonsillar hypertrophy (control group; n = 35). H pylori infection in the tonsillar biopsy samples was identified using histochemical and rapid urease tests.

Results:

The incidence of H pylori infection was significantly higher in the chronic tonsillitis group (56.5 per cent) compared to the control group (31.4 per cent). Similar findings were obtained for both subgroups of adults (68.6 vs 42.3 per cent) and children (40.7 vs 0.0 per cent). Significant relationships between a positive H pylori finding and laryngopharyngeal reflux related signs of vocal fold oedema, diffuse laryngeal oedema and hypertrophy of the posterior commissure were revealed.

Conclusion:

H pylori infection may be related to chronic tonsillitis and laryngopharyngeal reflux.

Keywords

Helicobacter PyloriTonsillitisHypertrophyLaryngopharyngeal Reflux
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 131 , Issue 6 , June 2017 , pp. 549 - 556
Copyright
Copyright © JLO (1984) Limited 2017 

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References

1 Kariya, S, Okano, M, Nishizaki, K. An association between Helicobacter pylori and upper respiratory tract disease: fact or fiction? World J Gastroenterol 2014;20:1470–84CrossRefGoogle ScholarPubMed
2 Malfertheiner, P, Megraud, F, O'Morain, CA, Atherton, J, Axon, AT, Bazzoli, F et al. Management of Helicobacter pylori infection—the Maastricht IV/ Florence Consensus Report. Gut 2012;61:646–64CrossRefGoogle ScholarPubMed
3 Yilmaz, T, Ceylan, M, Akyon, Y, Ozçakýr, O, Gürsel, B. Helicobacter pylori: a possible association with otitis media with effusion. Otolaryngol Head Neck Surg 2006;134:772–7CrossRefGoogle ScholarPubMed
4 Siupsinskiene, N, Jurgutaviciute, V, Katutiene, I, Janciauskas, D, Vaitkus, S, Adamonis, K. Helicobacter pylori infection in laryngeal diseases. Eur Arch Otorhinolaryngol 2013;270:2283–8CrossRefGoogle ScholarPubMed
5 Lukeš, P, Pavlík, E, Potuznikova, B, Nartova, E, Foltynova, E, Plzak, J et al. Detection of Helicobacter pylori in oropharyngeal lymphatic tissue with real-time PCR and assessment of its carcinogenic potential. Eur Arch Otorhinolaryngol 2014;271:399–405 CrossRefGoogle ScholarPubMed
6 Kaptan, ZK, Emir, H, Uzunkulaoğlu, H, Yücel, M, Karakoç, E, Koca, G et al. Determination of Helicobacter pylori in patients with chronic nonspecific pharyngitis. Laryngoscope 2009;119:1479–83CrossRefGoogle ScholarPubMed
7 Yemisen, M, Mete, B, Kanbay, A, Balkan, II, Ozaras, R. The role of Helicobacter pylori in upper respiratory system infections: is it more than colonization? Curr Infect Dis Rep 2012;14:128–36CrossRefGoogle ScholarPubMed
8 Kurtaran, H, Uyar, ME, Kasapoglu, B, Turkay, C, Yilmaz, T, Akcay, A et al. Role of Helicobacter pylori in pathogenesis of upper respiratory system diseases. J Natl Med Assoc 2008;100:1224–30Google ScholarPubMed
9 Kusano, K, Inokuchi, A, Fujimoto, K, Miyamoto, H, Tokunaga, O, Kuratomi, Y et al. Coccoid Helicobacter pylori exists in the palatine tonsils of patients with IgA nephropathy. J Gastroenterol 2010;45:406–12CrossRefGoogle ScholarPubMed
10 Jabbari Moghaddam, Y, Rafeey, M, Radfar, R. Comparative assessment of Helicobacter pylori colonization in children tonsillar tissues. Int J Pediatr Otorhinolaryngol 2009;73:1199–201CrossRefGoogle ScholarPubMed
11 Wibawa, T, Surono, A, Widodo, I. Isolation of viable Helicobacter pylori in the tonsillar tissues of chronic tonsillitis patients. J Infect Dev Ctries 2011;5:561–4CrossRefGoogle ScholarPubMed
12 Dagtekin-Ergur, EN, Eren, F, Ustun, MB, Eren, Y, Taş, E, Gürsel, AO. Investigation of Helicobacter pylori colonization in pharyngeal and palatine tonsils with rapid urease test and immunohistochemical analysis [in Turkish]. Kulak Burun Bogaz Ihtis Derg 2008;18:85–9Google ScholarPubMed
13 Kraus, J, Nártová, E, Pavlík, E, Katra, R, Sterzl, I, Astl, J. Prevalence of Helicobacter pylori in adenotonsillar hypertrophy in children. Acta Otolaryngol 2014;134:88–92 CrossRefGoogle ScholarPubMed
14 Lin, HC, Wu, PY, Friedman, M, Chang, HW, Wilson, M. Difference of Helicobacter pylori colonization in recurrent inflammation and simple hyperplastic tonsil tissues. Arch Otolaryngol Head Neck Surg 2010;136:468–70CrossRefGoogle ScholarPubMed
15 Aslan, S, Yilmaz, I, Bal, N, Sener, M, Butros, R, Demirhan, B et al. Investigation of Helicobacter pylori in tonsillary tissue with Pronto Dry test and pathologic examination. Auris Nasus Larynx 2007;34:229–42CrossRefGoogle ScholarPubMed
16 Nártová, E, Kraus, J, Pavlík, E, Lukeš, P, Katra, R, Plzák, J et al. Presence of different genotypes of Helicobacter pylori in patients with chronic tonsillitis and sleep apnoea syndrome. Eur Arch Otorhinolaryngol 2014;271:607–13CrossRefGoogle ScholarPubMed
17 Abdel-Monem, MH, Magdy, EA, Nour, YA, Harfoush, RA, Ibreak, A. Detection of Helicobacter pylori in adenotonsillar tissue of children with chronic adenotonsillitis using rapid urease test, PCR and blood serology: a prospective study. Int J Pediatr Otorhinolaryngol 2011;75:568–72CrossRefGoogle ScholarPubMed
18 Farivar, TN, Pahlevan, A, Johari, P, Safdarian, F, Mehr, MA, Najafipour, R et al. Assessment of helicobacter pylori prevalence by scorpion real-time PCR in chronic tonsillitis patients. J Glob Infect Dis 2012;4:38–42 CrossRefGoogle ScholarPubMed
19 Bulut, Y, Agacayak, A, Karlidag, T, Toraman, ZA, Yilmaz, M. Association of cagA+ Helicobacter pylori with adenotonsillar hypertrophy. Tohoku J Exp Med 2006;209:229–33CrossRefGoogle ScholarPubMed
20 Jelavic, B, Bevanda, M, Ostojic, M, Leventic, M, Vasilj, M, Knezevic, E. Tonsillar colonization is unlikely to play important role in Helicobacter pylori infection in children. Int J Pediatr Otorhinolaryngol 2007;71:585–90CrossRefGoogle ScholarPubMed
21 Güçlü, O, Akçalı, A, Sahin, EM, Tekin, K, Barutçu, O, Otkun, MT et al. Relationship between Helicobacter pylori adenotonsillar colonization and frequency of adenotonsillitis in children. Balkan Med J 2013;30:301–4CrossRefGoogle ScholarPubMed
22 Eyigor, M, Eyigor, H, Gultekin, B, Aydin, N. Detection of Helicobacter pylori in adenotonsillar tissue specimens by rapid urease test and polymerase chain reaction. Eur Arch Otorhinolaryngol 2009;266:1611–13CrossRefGoogle ScholarPubMed
23 Toros, SZ, Toros, AB, Kaya, KS, Deveci, I, Özel, L, Naiboğlu, B et al. A study to detect Helicobacter pylori in adenotonsillar tissue. Ear Nose Throat J 2011;90:E32 CrossRefGoogle ScholarPubMed
24 Najafipour, R, Farivar, TN, Pahlevan, AA, Johari, P, Safdarian, F, Asefzadeh, M. Agreement rate of rapid urease test, conventional PCR, and scorpion real-time PCR in detecting helicobacter pylori from tonsillar samples of patients with chronic tonsillitis. J Glob Infect Dis 2012;4:106–9CrossRefGoogle ScholarPubMed
25 Fazaeli, A. State of the globe: diagnostic tests to detect Helicobacter pylori tonsillitis. J Glob Infect Dis 2012;4:99–101 CrossRefGoogle ScholarPubMed
26 Hwang, MS, Forman, SN, Kanter, JA, Friedman, M. Tonsillar Helicobacter pylori colonization in chronic tonsillitis: systematic review and meta-analysis. JAMA Otolaryngol Head Neck Surg 2015;141:245–9CrossRefGoogle ScholarPubMed
27 Cirak, MY, Ozdek, A, Yilmaz, D, Bayiz, U, Samim, E, Turet, S. Detection of Helicobacter pylori and its CagA gene in tonsils and adenoid tissues by PCR. Arch Otolaryngol Head Neck 2003;129:1225–9CrossRefGoogle ScholarPubMed
28 Baugh, R, Archer, S, Mitchell, R, Rosenfeld, RM, Amin, R, Burns, JJ et al. Clinical practice guideline: tonsillectomy in children. Otoloryngol Head Neck Surg 2011;144:S1–30 Google ScholarPubMed
29 Belafsky, PC, Postma, GN, Amin, MR, Koufman, JA. Symptoms and findings of laryngopharyngeal reflux. Ear Nose Thoat J 2002;81:10–13 Google ScholarPubMed
30 Jančiauskas, D. Histomorphological Changes of Gastric Mucosa in Functional Dyspepsia Patients and their Dynamics after Treatment with the Natural Antioxidant Astaxanthin (Dissertation). Kaunas: Kaunas Medical University, 2010 Google Scholar
31 Tseng, CA, Wang, WM, Wu, DC. Comparison of the clinical feasibility of three rapid urease tests in the diagnosis of Helicobacter pylori infection. Dig Dis Sci 2005;50:449–52CrossRefGoogle ScholarPubMed
32 Burne, RA, Chen, YY. Bacterial ureases in infectious diseases. Microbes Infect 2000;2:533–42CrossRefGoogle ScholarPubMed
33 Elsheikh, MN, Mahfouz, ME. Prevalence of Helicobacter pylori DNA in recurrent aphthous ulcerations in mucosa-associated lymphoid tissues of the pharynx. Arch Otolaryngol Head Neck Surg 2005;131:804–8CrossRefGoogle ScholarPubMed
34 Campagnolo, AM, Priston, J, Thoen, RH, Medeiros, T, Assunção, AR. Laryngopharyngeal reflux: diagnosis, treatment, and latest research. Int Arch Otorhinolaryngol 2014;18:184–91Google ScholarPubMed
35 Tezer, MS, Kockar, MC, Koçkar, O, Celik, A. Laryngopharyngeal reflux finding scores correlate with gastroesophageal reflux disease and Helicobacter pylori expression. Acta Otolaryngol 2006;126:958–61CrossRefGoogle ScholarPubMed
36 Zhang, JP, Peng, ZH, Zhang, J, Zhang, XH, Zheng, QY. Helicobacter pylori infection in the pharynx of patients with chronic pharyngitis detected with TDI-FP and modified Giemsa stain. World J Gastroenterol 2006;12:468–72CrossRefGoogle ScholarPubMed
37 Katra, R, Kabelka, Z, Jurovcik, M. Pilot study: association between Helicobacter pylori in adenoid hyperplasia and reflux episodes detected by multiple intraluminal impedance in children. Int J Pediatr Otorhinolaryngol 2014;78:1243–9CrossRefGoogle ScholarPubMed
38 Minocha, A, Raczkowski, CA, Richards, RJ. Is a history of tonsillectomy associated with a decreased risk of Helicobacter pylori infection? J Clin Gastroenterol 1997;25:580–2CrossRefGoogle ScholarPubMed
39 Sezen, OS, Kubilay, U, Erzin, Y, Tuncer, M, Unver, S. Does tonsillectomy affect the outcome of drug treatment for the eradication of gastric H pylori infection? A pilot study. Ear Nose Throat J 2013;92:127–32CrossRefGoogle ScholarPubMed