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Histological changes during progression of adenoid cystic carcinoma

Published online by Cambridge University Press:  29 June 2007

Yuzo Yamamoto ,
Tetsuro Saka ,
Kazuo Makimoto  and
Hiroaki Takahashi
Yuzo Yamamoto*
Affiliation:
Osaka, Japan
Tetsuro Saka
Affiliation:
Osaka, Japan
Kazuo Makimoto
Affiliation:
Osaka, Japan
Hiroaki Takahashi
Affiliation:
Osaka, Japan
*
Department of Otolaryngology, Osaka Medical College, Daigaku-cho, Takatsuki, Osaka 569, Japan. Fax: 0726-83-6070
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Abstract

Eight cases of adenoid cystic carcinoma were reviewed to determine whether and how the histological features of the tumour vary with the progress of the disease. The tumours were classified by their histological patterns as tubular, cribriform, trabecular or solid. The relative amount of each pattern seen in routine light microscopic sections was calculated histomorphometrically and compared in the primary tumour and recurrent and/or metastatic lesions in the same case. In the early stage, the tubular pattern predominated. Later, the highest percentage shifted to the cribriform, then to the trabecular and finally, in the late stage, to the solid pattern. There was no reverse direction of histological transformation from the solid to the tubular pattern. These results may help to explain previous reports that the tubular pattern usually represents a favourable prognosis, the solid pattern a poor prognosis and the cribriform pattern an intermediate prognosis.

Keywords

Carcinomaadenoid cysticHistology
Type
View from Beneath: Pathology in Focus
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 11 , November 1992 , pp. 1016 - 1020
Copyright
Copyright © JLO (1984) Limited 1992

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