Hostname: page-component-cd9895bd7-p9bg8 Total loading time: 0 Render date: 2024-12-27T10:09:53.345Z Has data issue: false hasContentIssue false
  • English
  • Français

Human papillomavirus and p53 oncoprotein in verrucous carcinoma of the larynx

Published online by Cambridge University Press:  29 June 2007

Manuel López-Amado ,
Tomás García-Caballero ,
Ascensión Lozano-Ramírez  and
Torcuato Labella-Caballero
Manuel López-Amado*
Affiliation:
Department of Otolaryngology, Catedra of Otolaryngology, School of Medicine, University of Santiago Compostela, La Coruña, Spain
Tomás García-Caballero
Affiliation:
Department of Pathologyt, Catedra of Otolaryngology, School of Medicine, University of Santiago Compostela, La Coruña, Spain
Ascensión Lozano-Ramírez
Affiliation:
Department of Pathologyt, Catedra of Otolaryngology, School of Medicine, University of Santiago Compostela, La Coruña, Spain
Torcuato Labella-Caballero
Affiliation:
Department of Otolaryngology, Catedra of Otolaryngology, School of Medicine, University of Santiago Compostela, La Coruña, Spain
*
Address for correspondence: Manuel López Amado (Servicio ORL), Avda, Carrero Blanco 16-2°D, 27002 Lugo, Spain. Fax: 07-34-81-178052
Get access Rights & Permissions [Opens in a new window]

Abstract

The incidence of p53 antigen and human papillomavirus (HPV) expression in archival formalin-fixed, paraffin-embedded tissue sections from verrucous carcinoma of the larynx was determined using immunohistochemistry.

The p53 oncoprotein was detected in four of 10 tissue samples (40 per cent). The same number of tumours had HPV antigen, and three cases had both p53 oncoprotein and HPV antigen. All positive cases were from heavy smokers and drinkers.

After surgical treatment, no tumour recurrence was present in our series. Four patients developed a second head and neck neoplasm and death occurred in three. Three of the patients with second tumour had p53 positive immunoreactivity and two had p13 and HPV expression.

Verrucous carcinoma of the larynx presented with overexpression of p53 antigen in a similar percentage to other head and neck cancers. The p53 immunohistochemical determination is well correlated with HPV detection and could have prognostic value in these tumours, but no statistical evidence was present.

Keywords

Laryngeal neoplasmshnmunohistochemistryPapillomavirusesDNA probes, HPV
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 110 , Issue 8 , August 1996 , pp. 742 - 747
Copyright
Copyright © JLO (1984) Limited 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abramson, A. L., Brandsma, J., Steimberg, B. M., Winkler, B. (1985) Verrucous carcinoma of the larynx: possible human papillomavirus etiology. Archives of Otolaryngology 111: 709–715.CrossRefGoogle ScholarPubMed
Clark, L. J., Mackenzie, K., Parkinson, E. K. (1993) Elevated levels of the p53 tumour suppressor protein in the basal layer of recurrent laryngeal papillomas. Clinical Otolaryngology 18: 63–65.CrossRefGoogle ScholarPubMed
Ćrum, C. P., Egawa, K., Fu, Y. S. (1983) Atipical immature metaplasia (AIM): a subset of human papillomavirus infection of the cervix. Cancer 51: 2214–2219.3.0.CO;2-2>CrossRefGoogle Scholar
Davidoff, A. M., Herndon, J. E., Glover, N. S., Kerns, B. J., Pence, J. C., Iglehart, J. D., Marks, J. R. (1991) Relation between p53 overexpression and established prognostic factors in breast cancer. Surgery 110: 259–264.Google ScholarPubMed
Dolcetti, R., Doglioni, C., Maestro, R., Gasparotto, D., Barzan, L., Pastore, A., Romanelli, M., Boiocchi, M. (1992) p53 over-expression is an early event in the development of human squamous-cell carcinoma of the larynx: genetic and prognostic implications. International Journal of Cancer 52: 178–182.CrossRefGoogle ScholarPubMed
Ferlito, A., Recher, G. (1980) Ackerman's tumour (verrucous carcinoma) of the larynx. A clinicopathologic study of 77 cases. Cancer 46: 1617–1630.3.0.CO;2-T>CrossRefGoogle ScholarPubMed
Field, J. K., Spandidos, D. A., Stell, P. M. (1992) Over-expression of the p53 gene in head and neck cancer, linked with heavy smoking and drinking. Lancet 339: 502–503.CrossRefGoogle Scholar
Field, J. K., Pavelic, Z. P., Spandidos, D. A., Stambrook, P. J., Jones, A. S., Gluckman, J. L. (1993) The role of the p53 tumour suppressor gene in squamous cell carcinoma of the head and neck. Archives of Otolaryngology, Head and Neck Surgery 119: 1118–1122.CrossRefGoogle ScholarPubMed
Hagen, P., Lyons, G. D., Haindel, C. (1993) Verrucous carcinoma of the larynx: role of human papillomavirus, radiation, and surgery. Laryngoscope 103: 253–257.CrossRefGoogle ScholarPubMed
Jenson, A. B., Kurman, R. J., Lancaster, W. D. (1991) Tissue effects of and host response to human papillomavirus infection. Dermatologic Clinics 9: 203–209.CrossRefGoogle ScholarPubMed
Kasperbauer, J. L., O'Halloran, G. L., Espy, M. J., Smith, T. F., Lewis, J. E. (1993) Polymerase chain reaction (PCR) identification of human papillomavirus (HPV) DNA in verrucous carcinoma of the larynx. Laryngoscope 103: 416–420.CrossRefGoogle ScholarPubMed
Lane, D. P., Benchimol, S. (1990) p53: Oncogene or antioncogene? Genes Dev 4: 1–8.CrossRefGoogle ScholarPubMed
Leedy, D. A., Trune, D. R., Kronz, J. D., Weidner, N., Cohen, J. I. (1994) Tumour angiogenesis, the p53 antigen, and cervical metastasis in squamous cell carcinoma of the tongue. Otolaryngology-Head and Neck Surgery 111: 417–422.CrossRefGoogle Scholar
Levi, J. E., Delcedo, R., Alberti, V. N., Torloni, H., Villa, L. L. (1989) Human papillomavirus DNA in respiratory papillomatosis detected by in situ hybridization and the polimerase chain reaction. American Journal of Pathology 135: 1179–1184.Google Scholar
Lundgren, J. A. V., Van Nostrand, A. W. P., Harwood, A. R. (1986) Verrucous carcinoma (Ackerman's tumour) of the larynx: diagnostic and therapeutic considerations. Head and Neck Surgery 9: 19–26.CrossRefGoogle ScholarPubMed
Mounts, P., Shah, K. V., Kashima, H. (1982) Viral etiology of juvenile and adult onset squamous papilloma of the larynx. Proceedings of the National Academy of Science of USA 79: 5425–5429.CrossRefGoogle ScholarPubMed
Noble-Topham, S. E., Fliss, D. M., Hartwick, R. W. J., Mclachlin, C. M., Freeman, J. L., Noyek, A. M., Andrulis, I. L. (1993) Detection and typing of human papillomavirus in verrucous carcinoma of the oral cavity using the polimerase chain reaction. Archives of Otolaryngology, Head and Neck Surgery 119: 1299–1304.CrossRefGoogle Scholar
Pavelic, Z. P., Portugal, L. G., Gootee, M. J., Stambrook, P. J., Smith, C., Mugge, R. E., Pavelic, L., Wilson, K., Buncher, R., Li, Y., McDonald, J. S., Gluckman, J. L. (1993) Retrieval of pil protein in paraffin-embedded head and neck tumour tissues. Archives of Otolaryngology, Head and Neck Surgery 119: 1206–1209.CrossRefGoogle Scholar
Steinberg, B. M., Gallagher, T., Stoler, M. (1988) Persistence and expression of human papillomavirus during interferon therapy. Archives of Otolarvngology, Head and Neck Surgery 114: 27–32.CrossRefGoogle ScholarPubMed
Sun, X. F., Carstensen, J. M., Zhan, H., Stal, O., Wingren, S., Hatschek, T., Nordenskjold, B. (1992) Prognosis significance of cytoplasmatic p53 oncQprotein in colorectal adenocarcinoma. Lancet 340: 1369–1373.CrossRefGoogle Scholar
Weber, R. S., Shillitoe, E. J., Robbins, K. T., Luna, M. A., Batsakis, J. G., Donovan, D. T., Adler-Storthz, K. (1988) Prevalence of human papillomavirus in inverted nasal papillomas. Archives of Otolaryngology, Head and Neck Surgery 114: 23–26.CrossRefGoogle ScholarPubMed