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Human papillomavirus tumour status is not associated with a positive depression screen for patients with oropharyngeal cancer

Published online by Cambridge University Press:  19 July 2017

J R Qualliotine ,
J A Califano ,
R J Li ,
D Gold ,
B Messing ,
G Lee ,
P Ha  and
C Fakhry
J R Qualliotine
Affiliation:
Department of Otolaryngology–Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, University of California, San Diego, USA
J A Califano
Affiliation:
Department of Otolaryngology–Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, University of California, San Diego, USA Milton J Dance Jr Head and Neck Center, Greater Baltimore Medical Center, Maryland, USA
R J Li
Affiliation:
Department of Otolaryngology–Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of Otolaryngology–Head and Neck Surgery, Oregon Health and Science University, Portland, USA
D Gold
Affiliation:
Milton J Dance Jr Head and Neck Center, Greater Baltimore Medical Center, Maryland, USA
B Messing
Affiliation:
Milton J Dance Jr Head and Neck Center, Greater Baltimore Medical Center, Maryland, USA
G Lee
Affiliation:
Milton J Dance Jr Head and Neck Center, Greater Baltimore Medical Center, Maryland, USA
P Ha
Affiliation:
Department of Otolaryngology–Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Milton J Dance Jr Head and Neck Center, Greater Baltimore Medical Center, Maryland, USA Department of Otolaryngology–Head and Neck Surgery, University of California, San Francisco, USA
C Fakhry*
Affiliation:
Department of Otolaryngology–Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Milton J Dance Jr Head and Neck Center, Greater Baltimore Medical Center, Maryland, USA
*
Address for correspondence: Dr Carole Fakhry, Department of Otolaryngology – Head and Neck Surgery, 601 N Caroline Street, JHOC 6th Floor, Baltimore, MD 21287, USA Fax: +01 (410) 955 6526 E-mail: cfakhry@jhmi.edu
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Abstract

Background:

Several risk factors for depression in patients with oropharyngeal cancer have been determined. However, it is unknown whether human papillomavirus associated oropharyngeal cancer, which has a distinct clinico-demographic profile, modulates this risk.

Methods:

A retrospective analysis was conducted of patients with oropharyngeal cancer. These patients had completed a 10-item depression screening questionnaire before receiving treatment for their disease from 2011 to 2014. Associations between patient or disease characteristics and depression screening questionnaire results were investigated.

Results:

The study comprised 69 patients, 31 (44.9 per cent) of whom screened positive for depression. There were no significant differences in distributions of clinico-demographic or histopathological characteristics, including human papillomavirus tumour status, by depression screen result.

Conclusion:

This population has a high risk for depression, but no obvious risk factors, including human papillomavirus tumour status, were associated with an elevated risk. This inability to risk-stratify patients by clinico-demographic or disease characteristics emphasises the importance of regular depression screening for all patients in this population.

Keywords

Oropharyngeal NeoplasmsSquamous Cell CarcinomaHead And Neck CancerPapillomaviridaeDepression
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 131 , Issue 9 , September 2017 , pp. 760 - 767
Copyright
Copyright © JLO (1984) Limited 2017 

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References

1 Waraich, P, Goldner, EM, Somers, J, Hsu, L. Prevalence and incidence studies of mood disorders: a systematic review of the literature. Can J Psychiatry 2004;49:124–38CrossRefGoogle ScholarPubMed
2 Krebber, AM, Buffart, LM, Kleijn, G, Riepma, IC, De Bree, R, Leemans, CR et al. Prevalence of depression in cancer patients: a meta-analysis of diagnostic interviews and self-report instruments. Psychooncology 2014;23:121–30CrossRefGoogle ScholarPubMed
3 Neilson, KA, Pollard, AC, Boonzaier, AM, Corry, J, Castle, DJ, Mead, KR et al. Psychological distress (depression and anxiety) in people with head and neck cancers. Med J Aust 2010;193:S48–51 Google Scholar
4 Kugaya, A, Akechi, T, Okuyama, T, Nakano, T, Mikami, I, Okamura, H et al. Prevalence, predictive factors, and screening for psychologic distress in patients with newly diagnosed head and neck cancer. Cancer 2000;88:2817–233.0.CO;2-N>CrossRefGoogle ScholarPubMed
5 Barber, B, Dergousoff, J, Nesbitt, M, Mitchell, N, Harris, J, O'Connell, D et al. Depression as a predictor of postoperative functional performance status (PFPS) and treatment adherence in head and neck cancer patients: a prospective study. J Otolaryngol Head Neck Surg 2015;44:38 CrossRefGoogle ScholarPubMed
6 Kim, S-A, Roh, J-L, Lee, S-A, Lee, S, Kim, S-B, Choi, S-H et al. Pretreatment depression as a prognostic indicator of survival and nutritional status in patients with head and neck cancer. Cancer 2016;122:131–40Google Scholar
7 Hammerlid, E, Silander, E, Hörnestam, L, Sullivan, M. Health-related quality of life three years after diagnosis of head and neck cancer--a longitudinal study. Head Neck 2001;23:113–25Google Scholar
8 Hall, RC, Wise, MG. The clinical and financial burden of mood disorders. Cost and outcome. Psychosomatics 1995;36:S11–18 Google Scholar
9 Beck, D, Koenig, H. Minor depression: a review of the literature. Int J Psychiatry Med 1996;26:177–209 Google Scholar
10 Yu, GP, Mehta, V, Branovan, D, Huang, Q, Schantz, S. Non-cancer-related deaths from suicide, cardiovascular disease, and pneumonia in patients with oral cavity and oropharyngeal squamous carcinoma. Arch Otolaryngol Head Neck Surg 2012;138:25–32 Google Scholar
11 Barber, B, Dergousoff, J, Slater, L, Harris, J, O'Connell, D, El-Hakim, H et al. Depression and survival in patients with head and neck cancer. JAMA Otolaryngol Neck Surg 2016;142:284–8Google Scholar
12 Newport, DJ, Nemeroff, CB. Review, assessment and treatment of depression in the cancer patient. J Psychosom Res 1998;45:215–37Google Scholar
13 Söllner, W, DeVries, A, Steixner, E, Lukas, P, Sprinzl, G, Rumpold, G et al. How successful are oncologists in identifying patient distress, perceived social support, and need for psychosocial counselling? Br J Cancer 2001;84:179–85Google Scholar
14 Vodermaier, A, Linden, W, Siu, C. Screening for emotional distress in cancer patients: a systematic review of assessment instruments. J Natl Cancer Inst 2009;101:1464–88Google Scholar
15 Hirschfeld, R, Weissman, M. Risk factors for major depression and bipolar disorder. In: Davis, KL, Charney, D, Coyle, JT, Nemeroff, C, eds. Neuropsychopharmacology. Philadelphia: Lippincott, Williams & Wilkins, 2002;1018–25Google Scholar
16 Katz, MR, Irish, JC, Devins, GM, Rodin, GM, Gullane, PJ. Psychosocial adjustment in head and neck cancer: the impact of disfigurement, gender and social support. Head Neck 2003;25:103–12CrossRefGoogle ScholarPubMed
17 Haisfield-Wolfe, ME, McGuire, DB, Soeken, K, Geiger-Brown, J, De Forge, BR. Prevalence and correlates of depression among patients with head and neck cancer: a systematic review of implications for research. Oncol Nurs Forum 2009;36:E107–25 CrossRefGoogle ScholarPubMed
18 Gillison, ML, D'Souza, G, Westra, W, Sugar, E, Xiao, W, Begum, S et al. Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst 2008;100:407–20Google Scholar
19 Baxi, SS, Shuman, AG, Corner, GW, Shuk, E, Sherman, EJ, Elkin, EB et al. Sharing a diagnosis of HPV-related head and neck cancer: the emotions, the confusion, and what patients want to know. Head Neck 2013;35:1534–41Google Scholar
20 Edge, SB, Byrd, DR, Compton, CC, Fritz, AG, Greene, FL, Trotti, A. Pharynx. In: Edge, SB, Byrd, DR, Compton, CC, Fritz, AG, Greene, FL, Trotti, A, eds. AJCC Cancer Staging Manual, 7th edn. New York: Springer, 2010;41–56 Google Scholar
21 Begum, S, Gillison, ML, Ansari-Lari, MA, Shah, K, Westra, WH. Detection of human papillomavirus in cervical lymph nodes: a highly effective strategy for localizing site of tumor origin. Clin Cancer Res 2003;9:6469–75Google Scholar
22 Eaton, WW, Muntaner, C, Smith, C, Tien, A, Ybarra, M. Center for Epidemiologic Studies Depression Scale: Review and revision (CESD and CESD-R). In: Maruish, ME, ed. The Use of Psychological Testing for Treatment Planning and Outcomes Assessment, 3rd edn. Mahwah, New Jersey: Lawrence Erlbaum, 2004;363–77Google Scholar
23 Irwin, M, Artin, KH, Oxman, MN. Screening for depression in the older adult: criterion validity of the 10-item Center for Epidemiological Studies Depression Scale (CES-D). Arch Intern Med 1999;159:1701–4CrossRefGoogle ScholarPubMed
24 Bjorgvinsson, T, Kertz, SJ, Bigda-Peyton, JS, McCoy, KL, Aderka, IM. Psychometric properties of the CES-D-10 in a psychiatric sample. Assessment 2013;20:429–36Google Scholar
25 Andresen, EM, Malmgren, JA, Carter, WB, Patrick, DL. Screening for depression in well older adults: evaluation of a short form of the CES-D (Center for Epidemiologic Studies Depression Scale). Am J Prev Med 1994;10:77–84 CrossRefGoogle Scholar
26 Tu, CH, Hsu, MC, Chi, SC, Lin, HY, Yen, YC. Routine depression screening and diagnosing strategy for cancer inpatients. Psychooncology 2014;23:1057–67Google Scholar
27 Adachi, Y, Kimura, H, Sato, N, Nagashima, W, Nakamura, K, Aleksic, B et al. Preoperative level of depression is a predictor of postoperative levels of depression in patients with head and neck cancer. Jpn J Clin Oncol 2014;44:311–17CrossRefGoogle ScholarPubMed
28 Neilson, K, Pollard, A, Boonzaier, A, Corry, J, Castle, D, Smith, D et al. A longitudinal study of distress (depression and anxiety) up to 18 months after radiotherapy for head and neck cancer. Psychooncology 2013;22:1843–8Google Scholar
29 Lydiatt, WM, Bessette, D, Schmid, KK, Sayles, H, Burke, WJ. Prevention of depression with escitalopram in patients undergoing treatment for head and neck cancer: randomized, double-blind, placebo-controlled clinical trial. JAMA Otolaryngol Neck Surg 2013;139:678–86Google ScholarPubMed
30 Milbury, K, Rosenthal, DI, El-Naggar, A, Badr, H. An exploratory study of the informational and psychosocial needs of patients with human papillomavirus-associated oropharyngeal cancer. Oral Oncol 2013;49:1067–71Google Scholar
31 Hess, CB, Rash, DL, Daly, ME, Farwell, DG, Bishop, J, Vaughan, AT et al. Competing causes of death and medical comorbidities among patients with human papillomavirus-positive vs human papillomavirus-negative oropharyngeal carcinoma and impact on adherence to radiotherapy. JAMA Otolaryngol Head Neck Surg 2014;140:312–16Google Scholar
32 Moubayed, SP, Sampalis, JS, Ayad, T, Guertin, L, Bissada, E, Gologan, OE et al. Predicting depression and quality of life among long-term head and neck cancer survivors. Otolaryngol Head Neck Surg 2015;152:91–7CrossRefGoogle ScholarPubMed
33 Koch, R, Wittekindt, C, Altendorf-Hoffmann, A, Singer, S, Guntinas-Lichius, O. Employment pathways and work-related issues in head and neck cancer survivors. Head Neck 2015;37:585–93CrossRefGoogle ScholarPubMed
34 Pinquart, M, Duberstein, P. Depression and cancer mortality: a meta-analysis. Psychol Med 2010;40:1797–810Google Scholar