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Immunoglobulin G4 related disease isolated to the nasal cavity: a rare cause of nasal obstruction

Published online by Cambridge University Press:  27 August 2014

C Morris ,
T Ng ,
P Kevin  and
N Singh
C Morris
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Westmead Hospital, University of Sydney, NSW, Australia
T Ng
Affiliation:
Department of Tissue Pathology, ICPMR, Westmead Hospital, Westmead, NSW, Australia
P Kevin
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Westmead Hospital, University of Sydney, NSW, Australia
N Singh*
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Westmead Hospital, University of Sydney, NSW, Australia
*
Address for correspondence: Dr Narinder Singh, Department of Otolaryngology, Head and Neck Surgery, Westmead Hospital/University of Sydney, Sydney, NSW 2145, Australia Fax: +612 9893 7440 E-mail: narinder@ents.com.au
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Abstract

Background:

Immunoglobulin G4 related disease is a rare condition. Cases involving the sinonasal region are exceptionally uncommon. This paper describes a case of immunoglobulin G4 related disease isolated solely to the nasal cavity.

Methods:

Case report and literature review.

Results:

A 34-year-old man presented with painless, progressive bilateral nasal obstruction. Clinical examination and imaging findings demonstrated bilateral submucosal swelling of the anterior septum and right external nasal wall. Biopsy revealed immunoglobulin G4 related disease. The patient responded to oral corticosteroids initially, followed by long-term methotrexate.

Conclusion:

To the best of our knowledge, this case represents the first report in the literature of immunoglobulin G4 related disease isolated solely to the nasal cavity.

Keywords

IgG4IgG4-Related Sclerosing DiseaseIgG4-Related DiseaseNasal CavityNasal ObstructionImmunoglobulin GMethotrexateAutoimmune DiseaseEosinophils
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 129 , Issue S1 , January 2015 , pp. S57 - S59
Copyright
Copyright © JLO (1984) Limited 2014 

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Footnotes

Presented as a poster at the Australian Society of Otolaryngology Head and Neck Surgery annual scientific meeting, 3–7 April 2011, Melbourne, Australia.

References

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