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Impact of pre-operative serum 25-hydroxyvitamin D on post-operative serum calcium in patients undergoing total thyroidectomy for benign goitre: retrospective study of 246 patients

Published online by Cambridge University Press:  06 September 2017

M Erlem ,
N Klopp-Dutote ,
A Biet-Hornstein ,
V Strunski  and
C Page
M Erlem
Affiliation:
Department of ENT and Head and Neck Surgery, University Hospital, Amiens, France
N Klopp-Dutote
Affiliation:
Department of ENT and Head and Neck Surgery, University Hospital, Amiens, France
A Biet-Hornstein
Affiliation:
Department of ENT and Head and Neck Surgery, University Hospital, Amiens, France
V Strunski
Affiliation:
Department of ENT and Head and Neck Surgery, University Hospital, Amiens, France
C Page*
Affiliation:
Department of ENT and Head and Neck Surgery, University Hospital, Amiens, France
*
Address for correspondence: Dr Cyril Page, Service d'ORL et de chirurgie de la face et du cou, Centre Hospitalier Sud, 80054 Amiens Cedex, France E-mail: cyril_page@yahoo.fr
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Abstract

Objective:

To determine whether pre-operative serum 25-hydroxyvitamin D has an impact on post-operative parathyroid hormone and serum calcium levels in patients undergoing total thyroidectomy for benign goitre.

Methods:

This single-centre, retrospective study comprised 246 unselected surgical patients who had undergone total thyroidectomy for bilateral, benign, multinodular goitre. The correlation between pre-operative serum 25-hydroxyvitamin D and post-operative serum parathyroid hormone and serum calcium was studied to determine whether low pre-operative serum 25-hydroxyvitamin D was predictive of post-operative hypocalcaemia.

Results:

Seventy-nine patients (32 per cent) had post-operative hypocalcaemia. Eighteen patients (7.32 per cent) experienced unintentional parathyroidectomy (1 parathyroid gland in 15 patients, 2 parathyroid glands in 3 patients). In univariate analysis, pre-operative serum 25-hydroxyvitamin D was not correlated with post-operative serum calcium (p = 0.69) or post-operative serum parathyroid hormone (p = 0.5804). Furthermore, in multivariate analysis, which took into account unintentional parathyroidectomy, no correlation was found (p = 0.33). Bilateral unintentional parathyroidectomy was statistically associated with post-operative hypocalcaemia (p = 0.032).

Conclusion:

Pre-operative serum 25-hydroxyvitamin D did not appear to have any impact on post-operative serum calcium in patients undergoing total thyroidectomy for benign goitre.

Keywords

ThyroidectomyHypocalcemiaHypoparathyroidismVitamin DParathyroid Hormone
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 131 , Issue 10 , October 2017 , pp. 925 - 929
Copyright
Copyright © JLO (1984) Limited 2017 

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