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Influence of the mode of preparation on the long-term efficacy of homologous costal cartilage implants

Published online by Cambridge University Press:  29 June 2007

P. Adlington ,
A. J. Anscombe  and
J. J. Pmllips
P. Adlington
Affiliation:
From the Departments of ENT, Swansea
A. J. Anscombe
Affiliation:
From the Departments of Pathology, Swansea
J. J. Pmllips
Affiliation:
Bournemouth and the Department of ENT, Swansea.
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Abstract

Devitalized homologous costal cartilage is widely employed as an implant in the management of the saddle nose. The tissue response induced by the implant is a combination of enveloping fibrosis and implant resorption, which will probably, ultimately, be complete. We have studied the balance between resorption and fibrosis, following different modes of cartilage preparation, in the mouse. Homologous costal cartilage was devitalized by four common methods—irradiation, formalin, glutaraldehyde and alochol. Segments of this cartilage were inserted at separate sites in the subcutaneous plain of the tail. These implants were harvested after one year for histology. Variations in the mode of cartilage devitalization, while inducing variations in the degree of the tissue response, did not influence the balance between fibrosis and resorption. Thus the long term maintenance of tissue bulk following homologous cartilage implantation is not influenced by the mode of preparation. Evidence suggests that the ultimate cosmetic results of autologous and homologous costal cartilage implantation would be much the same, and the use of homologous cartilage must be justified on other grounds.

Keywords

CartilageTransplantationHomologous
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 6 , June 1992 , pp. 511 - 517
Copyright
Copyright © JLO (1984) Limited 1992

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