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Intratympanic methylprednisolone as first-line therapy in sudden sensorineural hearing loss: preliminary results from a case–control series

Published online by Cambridge University Press:  02 August 2011

I Dallan ,
S Fortunato ,
A P Casani ,
E Panicucci ,
S Berrettini ,
R Lenzi  and
A Nacci
I Dallan
Affiliation:
ENT Unit, Azienda Ospedaliero Universitaria Pisana, Italy
S Fortunato*
Affiliation:
ENT Unit, Azienda Ospedaliero Universitaria Pisana, Italy
A P Casani
Affiliation:
ENT Unit, Azienda Ospedaliero Universitaria Pisana, Italy
E Panicucci
Affiliation:
Department of Experimental Pathology, University of Pisa, Italy
S Berrettini
Affiliation:
ENT Unit, Azienda Ospedaliero Universitaria Pisana, Italy
R Lenzi
Affiliation:
ENT Unit, Azienda Ospedaliero Universitaria Pisana, Italy
A Nacci
Affiliation:
ENT Unit, Azienda Ospedaliero Universitaria Pisana, Italy
*
Address for correspondence: Dr Susanna Fortunato, ENT Unit, Azienda Ospedaliero Universitaria Pisana, Via Paradisa 3, 56126 Pisa, Italy Fax: +39 050 997517 E-mail: susanna.fortunato@gmail.com
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Abstract

Background:

Sudden sensorineural hearing loss is a true audiological emergency, and its management is much discussed. Currently, no single therapy has been proven effective according to evidence criteria. Recently, intratympanic application of steroids has been increasingly used in refractory cases; however, it has only rarely been reported as first-line therapy.

Materials and methods:

Twenty consecutive patients with sudden sensorineural hearing loss treated between July 2008 and January 2010 were enrolled in this prospective, case–control study. Ten patients were treated with intratympanic steroids and 10 with systemic ‘shotgun’ therapy (including steroids, pentoxifylline, low molecular weight heparin and vitamin E). The two groups were homogeneous in all respects. Pure tone averages were assessed before and after treatment for both groups.

Results:

There were no statistically significant differences between the two groups.

Conclusion:

Intratympanic steroids seem to offer a valid alternative to systemic therapy, with few risks, in sudden sensorineural hearing loss patients, and we recommend their use as first-line therapy.

Keywords

Intratympanic SteroidSudden Hearing LossSudden Deafness TherapySteroids Therapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 10 , October 2011 , pp. 1004 - 1008
Copyright
Copyright © JLO (1984) Limited 2011

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