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Intratympanic methylprednisolone perfusion as a salvage treatment for profound idiopathic sudden sensorineural hearing loss

Published online by Cambridge University Press:  14 March 2017

Y Dai ,
L Lu ,
J Hou ,
X Yang ,
H Li ,
Y Yang  and
W She
Y Dai
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, People's Republic of China Department of Otolaryngology – Head and Neck Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, People's Republic of China
L Lu
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, People's Republic of China
J Hou
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, People's Republic of China
X Yang
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, People's Republic of China
H Li
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, People's Republic of China
Y Yang
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, People's Republic of China
W She*
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, People's Republic of China Department of Otolaryngology – Head and Neck Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, People's Republic of China
*
Address for correspondence: Prof. W She, Department of Otolaryngology – Head and Neck Surgery, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, 321 Zhongshan Road, Nanjing, 210008, People's Republic of China Fax: +86 25 8331 7016 E-mail: shewandong@163.com
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Abstract

Objective:

This study aimed to examine the effectiveness of intratympanic methylprednisolone perfusion as salvage treatment for profound idiopathic sudden sensorineural hearing loss.

Methods:

A retrospective clinical study of 97 patients with unilateral profound idiopathic sudden sensorineural hearing loss was performed. In all, 83 patients who received salvage intratympanic methylprednisolone perfusion plus conventional treatment (except for steroids) as the second-line therapy were assigned to the study group, while 14 patients who received conventional treatment alone were assigned to the comparison group.

Results:

In the study group, treatments in patients with a shorter interval from disease onset to intratympanic methylprednisolone perfusion (up to 15 days) had significantly greater improvements in the overall effective rate and pure tone average compared with patients with a longer interval (over 15 days). For patients with a short interval from disease onset to intratympanic methylprednisolone perfusion, those in the study group had significantly greater improvements in the overall effective rate and pure tone average compared with those in the comparison group. In both the study and comparison groups, hearing improvements were greater at low frequencies than at medium and high frequencies.

Conclusion:

The interval from disease onset to intratympanic methylprednisolone perfusion was the major factor affecting hearing recovery. Early second-line salvage intratympanic methylprednisolone perfusion significantly improved the degree of hearing recovery in profound idiopathic sudden sensorineural hearing loss patients after failure of systemic steroid treatment.

Keywords

Hearing LossPerfusion, MethylprednisoloneSalvage Therapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 131 , Issue 5 , May 2017 , pp. 404 - 410
Copyright
Copyright © JLO (1984) Limited 2017 

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