Hostname: page-component-cd9895bd7-8ctnn Total loading time: 0 Render date: 2024-12-27T08:33:16.352Z Has data issue: false hasContentIssue false
  • English
  • Français

Kimura's disease: clinicopathological study of eight cases

Published online by Cambridge University Press:  08 January 2013

R P S Punia ,
R Aulakh ,
S Garg ,
R Chopra ,
H Mohan  and
A Dalal
R P S Punia*
Affiliation:
Department of Pathology, Government Medical College and Hospital, Chandigarh, India
R Aulakh
Affiliation:
Department of Pathology, Government Medical College and Hospital, Chandigarh, India
S Garg
Affiliation:
Department of Pathology, Government Medical College and Hospital, Chandigarh, India
R Chopra
Affiliation:
Department of Pathology, Government Medical College and Hospital, Chandigarh, India
H Mohan
Affiliation:
Department of Pathology, Government Medical College and Hospital, Chandigarh, India
A Dalal
Affiliation:
Department of General Surgery, Government Medical College and Hospital, Chandigarh, India
*
Address for correspondence: Dr R P S Punia, Department of Pathology, Government Medical College and Hospital, Sector 32, Chandigarh-160030, India Fax: +91 172 266 5375 E-mail: drpunia@gmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Kimura's disease is a rare, localised, chronic inflammatory disease. This benign disease involves subcutaneous tissues, the major salivary gland, and lymph nodes primarily in the head and neck area.

Method:

Clinical details and stained slides of all cases reported as Kimura's disease over a 10-year period were reviewed.

Results:

There were eight cases of Kimura's disease. The mean age of patients was 22.8 years. One case showed associated nephrotic syndrome and two cases were associated with peripheral blood eosinophilia. All cases showed the typical histopathological features of Kimura's disease.

Conclusion:

Kimura's disease was first reported in China in 1937. The cause of Kimura's disease is unknown and many theories have been proposed. The eight cases reported here illustrate some of the variations in the mode of presentation and in the histological features of Kimura's disease. Kimura's disease should be considered in the differential diagnosis of patients who present with head and neck swellings and lymphadenopathy, and investigated accordingly.

Keywords

Kimura DiseaseNeckLymphadenopathyNephrotic SyndromeAngiolymphoid Hyperplasia With Eosinophilia
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 2 , February 2013 , pp. 170 - 174
Copyright
Copyright © JLO (1984) Limited 2013

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Weiss, SW, Goldblum, JR. Benign tumours and tumour-like lesions of blood vessels. In: Enzinger, FM, Weiss, SW, eds. Soft Tissue Tumors, 4th edn.Philadelphia: Mosby, 2001;837–90Google Scholar
2Abuel-Haija, M, Hurford, MT. Kimura disease. Arch Pathol Lab Med 2007;131:650–1CrossRefGoogle ScholarPubMed
3Mrówka-Kata, K, Kata, D, Kyrcz-Krzemien, S, Helbig, G. Kikuchi-Fujimoto and Kimura diseases: the selected, rare causes of neck lymphadenopathy. Eur Arch Otorhinolaryngol 2010;267:5–11CrossRefGoogle ScholarPubMed
4Kuo, TT, Shih, LY, Chan, HL. Kimura's disease. Involvement of regional lymph nodes and distinction from angiolymphoid hyperplasia with eosinophilia. Am J Surg Pathol 1988;12:843–54CrossRefGoogle ScholarPubMed
5Kimm, HT, Szeto, C. Eosinophilic hyperplastic lymphogranuloma, comparison with Mikulicz's disease [Chinese]. Proc Chin Med Soc 1937;1:329Google Scholar
6Kimura, T, Yoshimura, S, Ishikawa, E. On the unusual granulation combined with hyperplastic changes of lymphatic tissues [Japanese]. Trans Soc Pathol Jpn 1948;37:179–80Google Scholar
7Matsuda, O, Makiguchi, K, Ishibashi, K, Chida, Y, Ida, T, Matsuda, K et al. Long-term effects of steroid treatment on nephrotic syndrome associated with Kimura's disease and a review of the literature. Clin Nephrol 1992;37:119–23Google Scholar
8Chen, H, Thompson, LD, Aguilera, NS, Abbondanzo, SL. Kimura's disease. A clinicopathologic study of 21 cases. Am J Surg Pathol 2004;28:505–13CrossRefGoogle ScholarPubMed
9Jang, KA, Ahn, SJ, Choi, JH, Sung, KJ, Moon, KC, Koh, JK et al. Polymerase chain reaction (PCR) for human herpes virus 8 and heteroduplex PCR for clonality assessment in angiolymphoid hyperplasia with eosinophilia and Kimura's disease. J Cutan Pathol 2001;28:363–7CrossRefGoogle ScholarPubMed
10Mitsui, M, Ogino, S, Ochi, K, Ohashi, T. Three cases of eosinophilic lymph-folliculoid granuloma of the soft tissue originating from the parotid gland. Acta Otolaryngol Suppl 1996;522:130–2Google Scholar
11Viswanatha, B. Kimura's disease in children: a 9 years prospective study. Int J Pediatr Otorhinolaryngol 2007;71:1521–5CrossRefGoogle ScholarPubMed
12Tseng, CF, Lin, HC, Huang, SC, Su, CY. Kimura's disease presenting as bilateral parotid masses. Eur Arch Otorhinolaryngol 2005;262:8–10CrossRefGoogle ScholarPubMed
13Kung, IT, Gibson, JB, Bannatyne, PM. Kimura's disease: a clinico-pathological study of 21 cases and its distinction from angiolymphoid hyperplasia with eosinophilia. Pathology 1984;16:39–44CrossRefGoogle ScholarPubMed
14Yuen, HW, Goh, YH, Low, WK, Lim-Tan, SK. Kimura's disease: a diagnostic and therapeutic challenge. Singapore Med J 2005;46:179–83Google ScholarPubMed
15Day, TA, Abreo, F, Hoajsoe, DK, Aarstad, RF, Stucker, SJ. Treatment of Kimura's disease: a therapeutic enigma. Otolaryngol Head Neck Surg 1995;112:333–7CrossRefGoogle ScholarPubMed
16Kaneko, K, Aoki, M, Hattori, S, Sato, M, Kawana, S. Successful treatment of Kimura's disease with cyclosporine. J Am Acad Dermatol 1999;41:893–4CrossRefGoogle ScholarPubMed
17Hareyama, M, Oouchi, A, Nagakura, H, Asakura, K, Saito, A, Satoh, M et al. Radiotherapy for Kimura's disease: the optimum dosage. Int J Radiat Oncol Biol Phys 1998;40:647–51CrossRefGoogle ScholarPubMed