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Laryngeal aspergillosis in an acquired immunodeficiency syndrome patient

Published online by Cambridge University Press:  29 June 2007

C. Delbrouck ,
G. Chantrain ,
S. Kampouridis  and
M. Petein
C. Delbrouck*
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, C.H.U. Saint-Pierre, Belgium
G. Chantrain
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, C.H.U. Saint-Pierre, Belgium
S. Kampouridis
Affiliation:
Department of Radiology, C.H.U. Saint-Pierre, Belgium
M. Petein
Affiliation:
Department of Anatomopathology, Institut J. Bordet, Université Libre de Bruxelles, Belgium
*
Address for corresapondence: C. Delbrouck, Service d'ORL et de Chirurgie Cervico-faciale, CHU Saint-Pierre, 322, rue Haute, 1000 Bruxelles, Belgium
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Abstract

Aspergillosis is a rare infection. It varies considerably in its virulence depending on whether or not the patient affected is immunodepressed. The serious form is characterized by vascular invasion with haematogenic dissemination, tissue infarction andnecrosis. The most often affected site is the lung. A laryngeal localization is exceptional and usually results from dissemination from a lower airways portal of entry. Diagnosisis difficult: cultures are only positive in 50 per cent of cases, while in 60 per cent of cases the characteristic histological features reminiscent of sprigs of mistletoe are only found on postmortem examination. In view of the high morbidity and mortality in acquired immunodeficiency syndrome (AIDS) sufferers, this condition must be treated early and aggressively. Treatment is based essentially on amphotericin B and itraconazole.

Keywords

AspergillosisLarynxAcquired immunodeficiency syndrome
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 5 , May 1998 , pp. 488 - 490
Copyright
Copyright © JLO (1984) Limited 1998

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