Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-10T13:44:15.632Z Has data issue: false hasContentIssue false
  • English
  • Français

Laryngeal cancer management in a small, rural, multidisciplinary team setting: 15-year review

Published online by Cambridge University Press:  02 December 2013

D W Hamilton ,
P J McMeekin ,
P Dyson  and
A K Robson
D W Hamilton*
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Cumberland Infirmary, Carlisle, UK
P J McMeekin
Affiliation:
Institute of Health and Society, Newcastle University, UK
P Dyson
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Cumberland Infirmary, Carlisle, UK
A K Robson
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Cumberland Infirmary, Carlisle, UK
*
Address for correspondence: Mr David Hamilton, Ear Nose and Throat Dept, Freeman Hospital, High Heaton, Newcastle upon Tyne NE7 7DN, UK E-mail: david.hamilton@ncl.ac.uk
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

The Cumberland Infirmary, Carlisle, serves a largely remote, rural population of 330 000. The aim of this study was to report the treatment and survival figures for patients treated for laryngeal cancer at this centre.

Methods:

The study included 209 consecutive patients with squamous cell carcinoma of the larynx diagnosed between 1996 and 2010 at the Cumberland Infirmary.

Results:

Disease-specific survival was 100 per cent for stage one, 76 per cent for stage two, 87 per cent for stage three and 46 per cent for stage four. In total, 76 patients (36 per cent) had a laryngectomy, either as primary treatment or as a salvage procedure.

Conclusion:

Our tumour-specific survival rate was very high, and this success may be due in part to high rates of surgical intervention. Survival data compared favourably with other centres, despite less radical radiotherapy regimes. Laryngeal cancer can be managed effectively in a small, relatively remote, multidisciplinary team setting.

Keywords

Laryngeal CancerSurvivalSurgeryLaryngectomy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 12 , December 2013 , pp. 1203 - 1207
Copyright
Copyright © JLO (1984) Limited 2013 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Presented as a poster at the British Academic Conference in Otolaryngology, 4–6 July 2012, Glasgow, Scotland, UK

References

1NHS Information Centre. National Head and Neck Cancer Audit 2010 (Amended). Leeds: NHS Information Centre, 2010Google Scholar
2Paleri, V, Wight, RG, Silver, CE, Haigentz, M Jr, Takes, RP, Bradley, PJ et al. Comorbidity in head and neck cancer: a critical appraisal and recommendations for practice. Oral Oncol 2010;46:712–19CrossRefGoogle ScholarPubMed
3Mehanna, H, West, CML, Nutting, C, Paleri, V. Head and neck cancer – Part 2: treatment and prognostic factors. BMJ 2010;341:c4690Google ScholarPubMed
4National Institute of Clinical Excellence. Improving Outcomes in Head and Neck Cancers – The Manual 2004. London: National Institute of Clinical Excellence, 2004;156Google Scholar
5Dey, P, Arnold, D, Wight, R, MacKenzie, K, Kelly, C, Wilson, JA. Radiotherapy versus open surgery versus endolaryngeal surgery (with or without laser) for early laryngeal squamous cell cancer. Cochrane Database Syst Rev 2002:(2)CD002027CrossRefGoogle ScholarPubMed
6Kaplan, E, Meier, P. Nonparametric estimation from incomplete observations. J Amer Statist Assn 1958;53:457–81CrossRefGoogle Scholar
7Karim-Kos, HE, de Vries, E, Soerjomataram, I, Lemmens, V, Siesling, S, Coebergh, JW. Recent trends of cancer in Europe: a combined approach of incidence, survival and mortality for 17 cancer sites since the 1990s. Eur J Cancer 2008;44:1345–89CrossRefGoogle ScholarPubMed
8Rachet, B, Quinn, MJ, Cooper, N, Coleman, MP. Survival from cancer of the larynx in England and Wales up to 2001. Br J Cancer 2008;99(suppl 1):S35–7CrossRefGoogle ScholarPubMed
9Hoffman, HT, Porter, K, Karnell, LH, Cooper, JS, Weber, RS, Langer, CJ et al. Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival. Laryngoscope 2006;116:1–13CrossRefGoogle ScholarPubMed
10Yuen, A, Medina, JE, Goepfert, H, Fletcher, G. Management of stage T3 and T4 glottic carcinomas. Am J Surg 1984;148:467–72CrossRefGoogle ScholarPubMed
11Department of Veterans Affairs Laryngeal Cancer Study Group. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med 1991;324:1685–90CrossRefGoogle Scholar
12Forastiere, AA, Goepfert, H, Maor, M, Pajak, TF, Weber, R, Morrison, W et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 2003;349:2091–8CrossRefGoogle ScholarPubMed
13Wolf, GT. Reexamining the treatment of advanced laryngeal cancer: the VA laryngeal cancer study revisited. Head Neck 2010;32:7–14CrossRefGoogle Scholar
14Chen, AY, Halpern, M. Factors predictive of survival in advanced laryngeal cancer. Arch Otolaryngol Head Neck Surg 2007;133:1270–6CrossRefGoogle ScholarPubMed
15Olsen, KD. Reexamining the treatment of advanced laryngeal cancer. Head Neck 2010;32:1–7CrossRefGoogle ScholarPubMed
16Holsinger, FC, Weber, RS. Swing of the surgical pendulum: a return to surgery for treatment of head and neck cancer in the 21st century? Int J Radiat Oncol Biol Phys 2007;69(suppl):S129–31CrossRefGoogle Scholar
17Scottish Intercollegiate Guidelines Network. Diagnosis and management of head and neck cancer. Edinburgh: Scottish Intercollegiate Guidelines Network, 2006Google Scholar
18Fowler, JF. Optimum overall times II: extended modelling for head and neck radiotherapy. Clin Oncol (R Coll Radiol) 2008;20:113–26CrossRefGoogle ScholarPubMed
19Abendstein, H, Nordgren, M, Boysen, M, Jannert, M, Silander, E, Ahlner-Elmqvist, M et al. Quality of life and head and neck cancer: a 5 year prospective study. Laryngoscope 2005;115:2183–92CrossRefGoogle ScholarPubMed
20Rogers, SN, Ahad, SA, Murphy, SA. A structured review and theme analysis of papers published on ‘quality of life’ in head and neck cancer: 2000–2005. Oral Oncol 2007;43:843–68CrossRefGoogle ScholarPubMed
21Paleri, V, Patterson, J. Use of gastrostomy in head and neck cancer: a systematic review to identify areas for future research. Clin Otolaryngol 2010;35:177–89CrossRefGoogle ScholarPubMed
22Moor, JW, Patterson, J, Kelly, C, Paleri, V. Prophylactic gastrostomy before chemoradiation in advanced head and neck cancer: a multiprofessional web-based survey to identify current practice and to analyse decision making. Clin Oncol (R Coll Radiol) 2010;22:192–8CrossRefGoogle ScholarPubMed
23Roland, NJ, Paleri, V, eds. Head and Neck Cancer: Multidisciplinary Management Guidelines, 4th edn.London: ENT UK, 2011Google Scholar