Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-27T10:20:33.505Z Has data issue: false hasContentIssue false
  • English
  • Français

Laryngeal preservation in cases of advanced laryngeal cancer treated with platinum based induction chemotherapy befire local treatment

Published online by Cambridge University Press:  29 June 2007

A. Nikolaou ,
G. Fountzilas ,
P. Kosmidis ,
C. Banis ,
K. Sobolos  and
J. Danilidis
A. Nikolaou*
Affiliation:
From Ahepa Hospital, Thessaloniki, and Metaxa Cancer Hospital, Piraeus.
G. Fountzilas
Affiliation:
From Ahepa Hospital, Thessaloniki, and Metaxa Cancer Hospital, Piraeus.
P. Kosmidis
Affiliation:
From Ahepa Hospital, Thessaloniki, and Metaxa Cancer Hospital, Piraeus.
C. Banis
Affiliation:
From Ahepa Hospital, Thessaloniki, and Metaxa Cancer Hospital, Piraeus.
K. Sobolos
Affiliation:
From Ahepa Hospital, Thessaloniki, and Metaxa Cancer Hospital, Piraeus.
J. Danilidis
Affiliation:
From Ahepa Hospital, Thessaloniki, and Metaxa Cancer Hospital, Piraeus.
*
Angelos Nikolaou, M.D., No. 1, Kimonos Voga Str., Thessaloniki, Greece.
Get access Rights & Permissions [Opens in a new window]

Abstract

In this study we analyse our preliminary results after treating 28 patients with locally advanced laryngeal cancer with platinum based induction chemotherapy followed by radiation therapy or surgery.

The median age of our patients was 60 (46–75) years and median performance status was 80 (60–100). In 18 of the 28 patients locoregional treatment was radiation therapy with an overall response of 94.4 per cent.

After a median follow-up of 26 (15–40) months 39.3 per cent of the whole group of patients are alive and disease-free and six (21.4 per cent) patients are alive and disease-free preserving their larynx.

We conclude that although more extensive studies with large groups of patients and longer follow-up is needed to reach definite conclusions, it seems that platinum based induction chemotheraophy can be used successfully in locally advanced laryngeal cancer followed by radiotherapy. In those cases who respond well. the patient's larynx is preserved without compromizing the overall survival.

Keywords

ChemotherapyLaryngeal neoplasms
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 105 , Issue 11 , November 1991 , pp. 930 - 933
Copyright
Copyright © JLO (1984) Limited 1991

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ackerman, L., Del Regato, J. (1977) Cancer (diagnosis, treatment and prognosis), 5th edition, The C. V. Mosby Company, St. Louis, p. 301–318.Google Scholar
Al-Kourainy, K., Kish, J., Ensley, J., Taparoglou, E., Jacobs, J., Weaver, A., Crissman, J., Cummings, G., Al Sarraf, M. (1987) Achievement of superioe survival for historically negative versus histologically positive complete responders to cirplatin combination in patients with locally advanced head and neck cancer. Cancer, 59: 233–238.3.0.CO;2-X>CrossRefGoogle Scholar
Al Sarraf, M. (1988) Head and neck cancer: Chemotherapy concepts. Seminars on Oncology, 15 (1): 70–85.Google ScholarPubMed
American Joint Committee on Cancer (1988) Manual for staging on cancer. 3rd edition. J. B. Lippincott, Philadelphia. p. 27–51.Google Scholar
Armitage, P. (1971) Statistical methods in medical research. Blackwell Scientific, Oxford. pp. 353–368.Google Scholar
Baker, S. R. (1988) Preservation of laryngeal function in patients with carcinoma of the larynx. Archives Otolaryngology Head Neck Surgery, 114: 621.Google Scholar
Fountzilas, G., Daniilidis, J., Sridhar, K., Fountzila-Kalogera, A., Zaramboukas, T., Sombolos, K., Destouni-Salem, E., Vritsios, A., Tourkantonis, A. (1990) Induction chemotherapy with a new regimen alternating cisplatin, flourouracil with motimycin, hydroxyurea and bleomycin in carcinomas of nasopharynx or other sites of the head and neck region. Cancer, 66: 1453–1460.3.0.CO;2-X>CrossRefGoogle ScholarPubMed
Fountzilas, G., Kosmidis, P., Markantonakis, P., Sridhar, K., Banis, K., Themelis, C., Fountzila-Kalogera, A., Avramidis, V. Sombolos, K., Vritsios, A., Daniilids, J. (1991) Carboplatin, Continuous infusion 5-fluorouracil and mid-cycle high dose methotrexate as initial treatment in patients with locally advanced head and neck cancer. (Tumori, in press).Google ScholarPubMed
Hong, W. K., Wolf, G. T., Fisher's, Spaulding M., Endicott, J., Laramore, G., Hiliman, R., McClatchey, K., Fly, C. VACSP Coordination Centre (1989) Laryngeal preservation with inducation chemotherapy and radiotherapy in the treatment for advanced laryngeal cancer. Interim survival data of VACSP # 268. VA Laryngeal Cancer Study Group Proceedings of ASCO Vol. 8, no.650, 167.Google Scholar
Jacobs, C., Goffinet, D. R., Goffinet, L., Kohler, M., Fee, W. E. (1987) Chemotherapy as a substitute for surgery in the treatment of advanced resectable head and neck cancer (a report from the Northern California Oncology Group). Cancer, 60: 1178–1183.3.0.CO;2-S>CrossRefGoogle ScholarPubMed
Kaplan, H. S., Meier, P. (1958) Non-parametric estimation from incomplete observations. American Statistics Association Journal, 55: 457–480.CrossRefGoogle Scholar
Kish, J., Drelichman, A., Jacobs, J., Hoscher, J., Kinzie, J., Loh, J., Weaver, A., Al-Sarraf, M. (1982) Clinical trial of cisplatin and 5FU infusion as initial treatment for advanced squamous cell carcinoma of the head and neck. Cancer Treatment Report, 66: 471–474.Google ScholarPubMed
Mantel, N. (1966) Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemotherapy Reports, 50: 163–170.Google ScholarPubMed
Pfister, D. G., Haines, I. E., Pfister, D. A., Vikram, B., Gluck, L., Harrison, L., Fass, D., Gerold, F., Spiro, R., Shah, J., Sessions, R., Strong, E., Bosi, G. J. (1989) Patient selection for larynx preservation in advanced head and neck cancer. (Abstr) Proceedings AACR, 30: 262.Google Scholar
Smith, R. R., Caulk, R., Jackson, L. L., Russell, W. (1961) End result of 600 laryngeal cancers using the American Joint Committee's method of classification and end-result reporting. Surgery, Gynecology and Obstetrics, 113: 435–444.Google Scholar