Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-27T22:50:40.023Z Has data issue: false hasContentIssue false
  • English
  • Français

Lymph node and distant metastases in patients with sinonasal carcinoma

Published online by Cambridge University Press:  29 June 2007

Mamoru Miyaguchi ,
Schun-ichi Sakai ,
Hitoshi Takashima  and
Hironobu Hosokawa
Mamoru Miyaguchi*
Affiliation:
Departments of OtolaryngologyKagawa Medical School. 1750-1 Miki-cho Kita-gun. Kagawa 761-07., Japan.
Schun-ichi Sakai
Affiliation:
Departments of OtolaryngologyKagawa Medical School. 1750-1 Miki-cho Kita-gun. Kagawa 761-07., Japan.
Hitoshi Takashima
Affiliation:
Departments of Radiologyt. Kagawa Medical School. 1750-1 Miki-cho Kita-gun. Kagawa 761-07., Japan.
Hironobu Hosokawa
Affiliation:
Departments of Radiologyt. Kagawa Medical School. 1750-1 Miki-cho Kita-gun. Kagawa 761-07., Japan.
*
Address for correspondence: M. Miyaguchi, Department of Otolaryngology, Kagawa Medical School. 1750-1 Miki-cho Kita-gun. Kagawa 761-07, Japan. Fax: (81)-878-98-8360
Get access Rights & Permissions [Opens in a new window]

Abstract

A retrospective analysis of 34 cases of sino-nasal squamous cell or undifferentiated carcinoma in patients admitted between 1984 and 1992 was undertaken. Multimodality therapy incorporated radiation, surgery and chemotherapy. The five-year survival rate was 53 per cent. The local control rate was 82 per cent. Patients died of local failure (six), distant metastases (six), lymph node metastases (one) and other causes (three). Twenty-eight patients with local control were separated into groups: G1–2 (well and moderately differentiated) and G3–4 (poorly differentiated and undifferentiated) and evaluated to find the association between differentiation and metastasis. Lymph node metastasis was not related to the degree of differentiation. Distant metastasis was significantly related to the degree of differentiation (Fisher's exact test: p = 0.007). The result of the combination therapy is poor for patients with poorly differentiated or undifferentiated carcinoma because of distant metastases. Adjuvant chemotherapy may be necessary for them to prevent distant metastasis.

Keywords

Paranasal sinus neoplasmsCarcinomasquamous cellNeoplasmmetastasis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 109 , Issue 4 , April 1995 , pp. 304 - 307
Copyright
Copyright © JLO (1984) Limited 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Giri, S. P. G., Reddy, E. K., Gemen, L. S., Krishman, L., Smalley, S. R., Evans, R. G. (1992) Management of advanced squamous cell carcinoma of the maxillary sinus. Cancer 69: 657–661.3.0.CO;2-7>CrossRefGoogle Scholar
Knegt, P. P., De Jong, P. C., Van Andel, J. G., De Boer, M. F., Eykenboom, W., Van Der Schans, E. (1985) Carcinoma of the paranasal sinuses. Result of a prospective pilot study. Cancer 56: 57–62.3.0.CO;2-#>CrossRefGoogle ScholarPubMed
Kondo, M., Inuyama, Y., Ando, Y., Tsutsui, T., Yamashita, S., Hashimoto, T., Kunieda, E., Uematsu, M., Hashimoto, S. (1984) Patterns of relapse of squamous cell carcinoma of the maxillary sinus. Cancer 53: 2206–2210.3.0.CO;2-J>CrossRefGoogle ScholarPubMed
Lindeman, P., Eklund, U., Petruson, B. (1987) Survival after surgical treatment in maxillary neoplasms of epithelial origin. Journal of Laryngology and Otology 101: 564–568.CrossRefGoogle ScholarPubMed
Sakai, S., Hohki, A., Fuchihata, H., Tanaka, Y. (1983a) Multidisciplinary treatment of maxillary sinus carcinoma. Cancer 52: 1360–1364.3.0.CO;2-#>CrossRefGoogle ScholarPubMed
Sakai, S., Murata, M., Sasaki, R., Tsujimoto, T., Miyaguchi, M., Hohki, A. (1983b) Combined therapy for maxillary sinus carcinoma with special reference to cryosurgery. Rhinology 21: 179–183.Google ScholarPubMed
Sisson, G. A., Toniumi, D. M., Atiyah, R. A. (1989) Paranasal sinus malignancy: a comprehensive update. Laryngoscope 99: 143–150.CrossRefGoogle ScholarPubMed
UICC (1987) TNM Classification of Malignant Tumours. Springer. Tokyo, pp 27–29.Google Scholar