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Management and clinical outcome of sinonasal teratocarcinosarcoma: single institution experience

Published online by Cambridge University Press:  16 February 2010

A Budrukkar ,
J P Agarwal ,
S Kane ,
M Siddha ,
S Ghosh Laskar ,
P Pai ,
V Murthy ,
M Sengar  and
A D'Cruz
A Budrukkar*
Affiliation:
Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai, India
J P Agarwal
Affiliation:
Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai, India
S Kane
Affiliation:
Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, India
M Siddha
Affiliation:
Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai, India
S Ghosh Laskar
Affiliation:
Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai, India
P Pai
Affiliation:
Department of Surgical Oncology, Tata Memorial Hospital, Parel, Mumbai, India
V Murthy
Affiliation:
Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai, India
M Sengar
Affiliation:
Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai, India
A D'Cruz
Affiliation:
Department of Surgical Oncology, Tata Memorial Hospital, Parel, Mumbai, India
*
Address for correspondence: Dr Ashwini Budrukkar, Assistant Professor, Department of Radiation Oncology, Tata Memorial Hospital, Ernest Borges Marg, Parel, Mumbai 400 012, India. Fax: +91 22 24146937 E-mail: ashwininb@yahoo.com
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Abstract

Purpose:

To study the outcome of patients with sinonasal teratocarcinosarcoma treated at a single institution.

Methods:

We reviewed the medical records of 22 patients with histopathologically proven sinonasal teratocarcinosarcoma diagnosed during the period 1993–2007. Treatment was completed in 16 patients.

Results:

Fourteen patients underwent surgery (six received craniofacial resection, four open surgery and four endoscopic resection); this was followed by radiation therapy with or without chemotherapy in 11 patients. Two patients received chemoradiation as the definitive treatment. At median follow up in surviving patients of 34 months (range one to 180 months), only five were controlled. Disease recurred in 11 patients, with a median time to recurrence of seven months. The two-year disease-free survival rate and the overall survival rate were 28 and 46 per cent, respectively.

Conclusion:

Sinonasal teratocarcinosarcoma appears to be an aggressive disease, with the majority of patients suffering locoregional failure. Multimodality treatment, in the form of a combination of surgery, radiation therapy and chemotherapy, appears to be the optimal approach.

Keywords

Paranasal Sinus NeoplasmsTeratocarcinosarcomaRadiationSurgery
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 7 , July 2010 , pp. 739 - 743
Copyright
Copyright © JLO (1984) Limited 2010

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