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Management of clinically diagnosed subacute rhinosinusitis in children under the age of two years: a randomized, controlled study

Published online by Cambridge University Press:  29 June 2006

D M El-Hennawi ,
A S Abou-Halawa  and
S R Zaher
D M El-Hennawi
Affiliation:
Otorhinolaryngology Department, Suez Canal University, Ismailia, Egypt
A S Abou-Halawa
Affiliation:
Otorhinolaryngology Department, Suez Canal University, Ismailia, Egypt
S R Zaher
Affiliation:
Paediatrics Department, Alexandria University Hospital, Alexandria, Egypt
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Abstract

Background: In children, a diagnosis of rhinosinusitis is usually made on clinical grounds. Subacute rhinosinusitis (SRS) may be the cause of persistent cough, low-grade fever, snoring, ear problems and difficult feeding in children under the age of two years.

Objective: To compare the efficacy of culture-based antibiotics and empiric amoxicillin–clavulanate (40 mg/kg/day) in treating SRS in children under the age of two years.

Study design: Randomized, controlled study.

Population: Sixty children with persistent nasal discharge and nasal obstruction (and other related symptoms) for 30–90 days.

Methods: Group one (n = 30) received culture-based antibiotics and group two (n = 30) were treated empirically with 40 mg/kg/day of amoxicillin–clavulanate. Treatment was continued for two weeks.

Results: At the end of the three-week follow-up period, statistically significant greater improvements in nasal obstruction (p = 0.037) and nasal discharge (p = 0.003) were seen in group one compared with group two.

Conclusion: culture-based antibiotics were more efficacious than empiric amoxicillin–clavulanate (40 mg/kg/day) in treating SRS in children under the age of two years.

Keywords

SinusitisBacteriologyChildAntibiotics
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 120 , Issue 10 , October 2006 , pp. 845 - 848
Copyright
2006 JLO (1984) Limited

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