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Methodology for studying the effects of topically applied ear drops on otoacoustic emissions in guinea pigs

Published online by Cambridge University Press:  08 March 2006

Lela Migirov  and
Mordechay Himmelfarb
Lela Migirov
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Sheba Medical Centre, Tel Hashomer, and the Audiology Centre in Tel Aviv Sourasky Medical Centre, Israel.
Mordechay Himmelfarb
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Sheba Medical Centre, Tel Hashomer, and Department of Otolaryngology in Tel Aviv Sourasky Medical Centre, Israel.
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Abstract

Testing of otoacoustic emissions (OAE) has been successfully applied to study outer hair cell function. We used this methodology to evaluate and compare the effect of topically applied normal saline, and gentamicin- and ciprofloxacin-containing drops into the middle ear of guinea pigs. All three solutions similarly decreased the distortion product OAE (DPOAE) and all three caused an inflammatory reaction in the guinea pig’s middle-ear. OAE failed to detect adequately the ototoxicity of topically administered drops in this animal model because the opening of the bulla affected DPOAE, and both inflamed middle-ear mucosa and osteoneogenesis caused a decrease in DPOAE amplitude.

This is the first report examining the influence of topically used otic drops on inner ear function as demonstrated by OAE.

Keywords

Otoacoustic EmissionsSpontaneousDrug ToxicityPharmaceutical Preparations
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 117 , Issue 9 , September 2003 , pp. 696 - 699
Copyright
© Royal Society of Medicine Press Limited 2003

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