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Neuroendocrine carcinomas of the larynx

Published online by Cambridge University Press:  29 June 2007

J. P. Logue ,
S. S. Banerjee ,
N. J. Slevin  and
S. Vasanthan
J. P. Logue*
Affiliation:
Department of Radiotherapy and Oncology, Christie Hospital, Manchester M20 9BX.
S. S. Banerjee
Affiliation:
Department of Histopathology, Christie Hospital, Manchester M20 9BX.
N. J. Slevin
Affiliation:
Department of Radiotherapy and Oncology, Christie Hospital, Manchester M20 9BX.
S. Vasanthan
Affiliation:
Department of Radiotherapy and Oncology, Christie Hospital, Manchester M20 9BX.
*
Dr J. P. Logue, Senior Registrar in Radiotherapy and Oncology, Christie Hospital, Wilmslow Road, Manchester M20 9BX.
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Abstract

The clinical and histopathological characteristics of seven cases of Moderately Differentiated Neuroendocrine Carcinomas (MDNEC) and two cases of Poorly Differentiated Neuroendocrine Carcinomas (PDNEC) have been reviewed. The tumours arose in the supraglottis of predominantly elderly men. Two cases had raised levels of urinary 5-hydroxy-indole-acetic acid at presentation but no case developed the carcinoid syndrome. PDNEC were histologically identical to the oat cell type carcinoma of the bronchus and were associated with an extremely aggressive clinical course with both patients dying of widespread metastases within one month of registration. MDNEC also metastasized frequently with four of seven cases dying with widespread disease. The tumours have previously been reported as not being radiosensitive; however three cases remain free of disease following biopsy and radiotherapy alone. The place of radiotherapy in the management of these tumours is discussed.

Keywords

Laryngeal neoplasmsCarcinomaneuroendocrine
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 105 , Issue 12 , December 1991 , pp. 1031 - 1035
Copyright
Copyright © JLO (1984) Limited 1991

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References

Blok, P. H. H. M., Manni, J. J., van den Broek, P., van Haelst, U. J. G. M., Sloof, J. L. (1985) Carcinoid of the larynx: a report of three cases and a review of the literature. Laryngoscope, 95: 715–719.CrossRefGoogle Scholar
Carles, D., Devars, F., Traissac, L., Darasse, D., Rinaldo, J. F., Richir, C. (1983) Carcinoide primitif du larynx. Annals of Pathology, 3: 65–68.Google ScholarPubMed
Ferlito, A., Friedmann, I., Goldman, N. C. (1988) Primary carcinoid tumour of the larynx. ORL-Journal for Oto-Rhinolaryngology and its related specialties, 50: 129–149.CrossRefGoogle ScholarPubMed
Giddings, N. A., Kennedy, T. L., Vrabec, D. P. (1987) Primary small cell carcinoma of the larynx: Analysis of treatment. Journal of Laryngology and Otology, 16: 157–160.Google ScholarPubMed
Goldman, N. C., Hood, I., Singleton, G. T. (1969) Carcinoid of the larynx. Archives of Otolaryngology, 90: 60–67.Google ScholarPubMed
Gnepp, D. R., Ferlito, A., Hyams, V. (1983) Primary anaplastic small cell (oat cell) carcinoma of the larynx. Cancer, 51: 1731–1745.3.0.CO;2-6>CrossRefGoogle ScholarPubMed
Milroy, C. M., Rode, J., Moss, E. (1991) Laryngeal paragangliomas and neuroendocrine carcinomas. Histopathology, 18: 201–209.CrossRefGoogle ScholarPubMed
Oberg, K., Funa, K., Alm, G. (1983) Effects of leucocyte Interferon on clinical symptoms and hormone levels in patients with mid-gut carcinoid tumours and carcinoid syndrome. New England Journal of Medicine, 309: 129–133.CrossRefGoogle ScholarPubMed
Wenig, B. M., Hyams, V. J., Heffner, D. K. (1988) Moderately differentiated neuroendocrine carcinoma of the larynx. A clinicopathological study of 54 cases. Cancer, 62: 2658–2676.3.0.CO;2-M>CrossRefGoogle ScholarPubMed
Wenig, B. M., Gnepp, D. R. (1989) The spectrum of neuroendocrine carcinomas of the larynx. Seminars in Diagnostic Pathology, 6:4:, 329–350.Google ScholarPubMed