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Neuroendocrine differentiation in head and neck squamous cell carcinoma

Published online by Cambridge University Press:  11 October 2012

V H Schartinger ,
C Falkeis ,
K Laimer ,
G M Sprinzl ,
H Riechelmann ,
M Rasse ,
I Virgolini  and
J Dudás
V H Schartinger*
Affiliation:
Department of Otorhinolaryngology, Medical University Innsbruck, Austria
C Falkeis
Affiliation:
Institute of Pathology, Medical University Innsbruck, Austria
K Laimer
Affiliation:
Department of Maxillofacial Surgery, Medical University Innsbruck, Austria
G M Sprinzl
Affiliation:
Department of Otorhinolaryngology, Medical University Innsbruck, Austria
H Riechelmann
Affiliation:
Department of Otorhinolaryngology, Medical University Innsbruck, Austria
M Rasse
Affiliation:
Department of Maxillofacial Surgery, Medical University Innsbruck, Austria
I Virgolini
Affiliation:
Department of Nuclear Medicine, Medical University Innsbruck, Austria
J Dudás
Affiliation:
Department of Otorhinolaryngology, Medical University Innsbruck, Austria
*
Address for correspondence: Volker H Schartinger, Department of Otorhinolaryngology, Medical University Innsbruck, Anichstrasse 35,6020 Innsbruck, Austria Fax: +43 512 504 23144 E-mail: volker.schartinger@i-med.ac.at
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Abstract

Objective:

Tumours with neuroendocrine differentiation frequently express chromogranin A, synaptophysin and somatostatin receptors. The role of neuroendocrine differentiation in head and neck squamous cell carcinoma is not yet clear.

Method:

The presence of chromogranin A, synaptophysin and somatostatin receptors was studied immunohistochemically in 78 head and neck squamous cell carcinoma specimens.

Results:

Sparse chromogranin A expression was found in 41 per cent, associated with high chromogranin A messenger RNA expression and the presence of dense core granules. Low synaptophysin expression was found in 18 per cent. The highest staining scores were found for somatostatin receptor 5 (82 per cent), followed by somatostatin receptor 1 (69 per cent) and somatostatin receptor 2 (54 per cent), whereas somatostatin receptors 3 and 4 expression was low. Expression was not correlated with tumour stage or survival.

Conclusion:

Cells with neuroendocrine differentiation are sparsely scattered in some head and neck squamous cell carcinomas. Their pathophysiological role is elusive. In contrast, somatostatin receptor and particularly somatostatin receptor 5 expression is frequent in head and neck squamous cell carcinoma. Somatostatin receptor expression is not considered to indicate neuroendocrine differentiation in head and neck squamous cell carcinoma.

Keywords

Head and Neck NeoplasmNeuroendocrine CellsImmunohistochemistry
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 12 , December 2012 , pp. 1261 - 1270
Copyright
Copyright © JLO (1984) Limited 2012

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