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Olfactory event-related potentials: a new approach for the evaluation of olfaction in nasopharyngeal carcinoma patients treated with chemo-radiotherapy

Published online by Cambridge University Press:  02 March 2016

B Galletti ,
R Santoro ,
V K Mannella ,
F Caminiti ,
L Bonanno ,
S De Salvo ,
G Cammaroto  and
F Galletti
B Galletti
Affiliation:
Department of Otorhinolaryngology, University of Messina, Messina, Italy
R Santoro
Affiliation:
Department of Otorhinolaryngology, University of Messina, Messina, Italy
V K Mannella
Affiliation:
Department of Otorhinolaryngology, University of Messina, Messina, Italy
F Caminiti
Affiliation:
Department of Research, Istituto di Ricovero e Cura a Carattere Scientifico (‘IRCCS’) Centro Neurolesi ‘Bonino Pulejo’, Messina, Italy
L Bonanno
Affiliation:
Department of Research, Istituto di Ricovero e Cura a Carattere Scientifico (‘IRCCS’) Centro Neurolesi ‘Bonino Pulejo’, Messina, Italy
S De Salvo
Affiliation:
Department of Research, Istituto di Ricovero e Cura a Carattere Scientifico (‘IRCCS’) Centro Neurolesi ‘Bonino Pulejo’, Messina, Italy
G Cammaroto*
Affiliation:
Department of Otorhinolaryngology, University of Messina, Messina, Italy
F Galletti
Affiliation:
Department of Otorhinolaryngology, University of Messina, Messina, Italy
*
Address for correspondence: Dr Giovanni Cammaroto, Department of Otorhinolaryngology, Policlinico Universitario, Via Consolare Valeria, 98100 Messina, Italy Fax: +39 (090) 221 2257 E-mail: giovanni.cammaroto@hotmail.com
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Abstract

Objective:

Olfactory dysfunction is a possible side effect of chemo-radiotherapy performed in patients affected by nasopharyngeal carcinoma. Self-rating measurements and olfactory event-related potentials were used and compared in order to evaluate the impact of this treatment on the olfactory system.

Methods:

Nine patients underwent subjective evaluation of olfactory function (using visual analogue scales for olfactory symptoms and quality of life, and a six-item Hyposmia Rating Scale), and a quantitative and objective measurement (olfactory event-related potentials).

Results:

Spearman's rank correlation analyses highlighted significant relationships between the clinical scales and olfactory event-related potentials. Inter-group analyses showed significant differences in the latency and in the amplitude of olfactory event-related potentials between patients and controls.

Conclusion:

Taking into account the small sample size and the lack of pre-treatment assessment, olfactory event-related potentials seemed to allow a more objective diagnosis of unilateral and bilateral olfactory loss. Moreover, olfactory event-related potentials and subjective scales results were concordant.

Keywords

Somatosensory Evoked Potentials; RadiotherapyChemotherapyNasopharyngeal CarcinomaOlfactory Perception
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 5 , May 2016 , pp. 453 - 461
Copyright
Copyright © JLO (1984) Limited 2016 

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