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Olfactory neuroblastoma: 14-year experience at an Australian tertiary centre and the role for longer-term surveillance

Published online by Cambridge University Press:  05 December 2016

C Schmidt ,
N Potter ,
S Porceddu  and
B Panizza
C Schmidt
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Princess Alexandra Hospital, Brisbane, Australia School of Medicine, University of Queensland, Brisbane, Australia
N Potter
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Princess Alexandra Hospital, Brisbane, Australia
S Porceddu
Affiliation:
School of Medicine, University of Queensland, Brisbane, Australia Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane, Australia
B Panizza*
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Princess Alexandra Hospital, Brisbane, Australia School of Medicine, University of Queensland, Brisbane, Australia
*
Address for correspondence: A/Prof Ben Panizza, Department of Otolaryngology, Head and Neck Surgery, Princess Alexandra Hospital, 199 Ipswich Rd, Woolloongabba 4102, Brisbane, Australia Fax: (+61) 07 3176 2427 E-mail: ben@panizza.com.au
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Abstract

Background:

Olfactory neuroblastoma is a rare sinonasal malignancy, with poorly defined treatment protocols. Management at a tertiary centre was retrospectively evaluated to inform future treatment and follow up.

Methods:

Cases treated with curative intent (2000–2014) were included. Data were collected, and overall and disease-free survival rates were calculated.

Results:

Eleven cases were identified, with a median follow up of 87 months. One patient was Kadish stage A, one was stage B, eight were stage C and one was stage D. The latter patient underwent chemoradiotherapy alone. The remaining patients proceeded to: endoscopic-assisted wide local excision (n = 2), anterior craniofacial resection (n = 4) or endoscopic craniofacial resection (n = 4). No patients had primary nodal disease or elective neck treatment. One patient had neoadjuvant chemoradiation. Six patients had post-operative radiotherapy; three received adjuvant chemotherapy. Two patients had late cervical node failure, and proceeded to neck dissection and post-operative radiotherapy. Two patients had late local recurrence. Ten-year overall and disease-free survival rates were 68.2 and 46.7 per cent, respectively.

Conclusion:

Longer-term follow up is supported given the incidence of late regional and local recurrence. Prophylactic treatment of cervical nodes in locally advanced disease is an area for further investigation.

Keywords

Olfactory NeuroblastomaEsthesioneuroblastomaSurveillanceRelapseSurvivalMetastasisNeoplasm
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 131 , Supplement S2: ASOHNS Supplement , July 2017 , pp. S29 - S34
Copyright
Copyright © JLO (1984) Limited 2016 

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