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Ototoxicity after use of neomycin eardrops is unrelated to A1555G point mutation in mitochondrial DNA

Published online by Cambridge University Press:  16 March 2006

Tatsuya Yamasoba  and
Katsunori Tsukuda
Tatsuya Yamasoba
Affiliation:
Department of Otolaryngology Head and Neck Surgery, University of Tokyo, Tokyo, Japan.
Katsunori Tsukuda
Affiliation:
Third Department of Internal Medicine, University of Tokyo, Tokyo, Japan.
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Abstract

Ear drops containing neomycin only rarely cause ototoxicity. The authors report on three patients with a tympanic membrane perforation who developed severe ototoxicity after use of eardrops containing 0.35 per cent neomycin. Mitochondrial DNA analysis revealed that there was no A1555G point mutation in these patients. This finding indicates that application of low concentration neomycin to the middle ear can cause severe inner ear damage even in humans who are not hyper-susceptible to aminoglycosides.

Keywords

NeomycinCochleaHearing LossSensorineuralVertigoMutationDrug Hypersensitivity
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 118 , Issue 7 , July 2004 , pp. 546 - 550
Copyright
© 2004 Royal Society of Medicine Press

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