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Parotid gland carcinoma: 32 years’ experience from a single institute

Published online by Cambridge University Press:  06 June 2019

T Nakano ,
R Yasumatsu ,
R Kogo ,
K Hashimoto ,
K Asai ,
S Ohga ,
H Yamamoto ,
T Nakashima  and
T Nakagawa
T Nakano*
Affiliation:
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Department of Head and Neck Surgery, National Kyushu Cancer Center, Fukuoka, Japan
R Yasumatsu
Affiliation:
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
R Kogo
Affiliation:
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
K Hashimoto
Affiliation:
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
K Asai
Affiliation:
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
S Ohga
Affiliation:
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
H Yamamoto
Affiliation:
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
T Nakashima
Affiliation:
Department of Otolaryngology, Kyushu Medical Center, Fukuoka, Japan
T Nakagawa
Affiliation:
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
*
Author for correspondence: Dr Takafumi Nakano, Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-3-1, Higashi-ku, Fukuoka 812-8582, Japan E-mail: tn01061@surgpath.med.kyushu-u.ac.jp Fax: +81 92 642 5685
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Abstract

Background

Parotid gland carcinoma is a rare and complicated histopathological classification. Therefore, assembling a sufficient number of cases with long-term outcomes in a single institute can present a challenge.

Method

The medical records of 108 parotid gland carcinoma patients who were treated at Kyushu University Hospital, Fukuoka, Japan, between 1983 and 2014 were reviewed. The survival outcomes were analysed according to clinicopathological findings.

Results

Forty-six patients had low clinical stage tumours (I–II), and 62 patients had high clinical stage tumours (III–IV). Fifty-two, 10 and 46 patients had low-, intermediate- and high-grade tumours, respectively. Twenty-seven of 65 cases had positive surgical margins. In high clinical stage and intermediate- to high-grade tumours, adjuvant radiation therapy was correlated with local recurrence-free survival (p = 0.0244). Intermediate- to high-grade tumours and positive surgical margins were significantly associated with disease-specific survival in multivariate analysis (p = 0.0002 and p = 0.0058).

Conclusion

The results of this study show that adjuvant radiation therapy is useful for improved local control in patients with high clinical stage and intermediate- to high-grade tumours.

Keywords

Salivary Gland CancerPrognosesRadiotherapy, AdjuvantNeoplasm Recurrence, Local
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 133 , Issue 7 , July 2019 , pp. 604 - 609
Copyright
Copyright © JLO (1984) Limited, 2019 

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Footnotes

Dr T Nakano takes responsibility for the integrity of the content of the paper

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