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Polypoidal carcinosarcoma of the oropharynx: a clinicopathological and immunohistochemical study

Published online by Cambridge University Press:  29 June 2007

Lars Trier Hansen ,
Søren Kristensenan  and
Jørgen Moesner
Lars Trier Hansen
Affiliation:
Departments of Otolaryngology, Central Hospital, Esbjerg, Denmark.
Søren Kristensenan*
Affiliation:
Departments of Otolaryngology, Central Hospital, Esbjerg, Denmark.
Jørgen Moesner
Affiliation:
Department of Pathology, Central Hospital, Esbjerg, Denmark.
*
Address for correspondence: Dr Søren Kristensen, Departments of Otolaryngology, Central Hospital, 6700 Esbjerg, Denmark.
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Abstract

Polypoidal squamous cell carcinomas, with a sarcomatous stroma, in the upper aerodigestive tract are very rare but well described tumours. They are associated with a multifario?sjiomenclature because of different opinions regarding their histology and histogenesis. The main issue is whether the stroma component is a true sarcoma or a benign reactive lesion.

In order to draw the attention of otolaryngologists and pathologists to the characteristic features of this rare tumour, two cases originating from the oropharynx are presented. Both tumours were pedunculated and polypoidal, and their bulk consisted of a bizarre sarcoma-like stroma covered with granulation tissue. In some areas of the surface, however, atypical squamous cell epithelium with foci of invasive carcinoma was found. In the vicinity of the latter both tumours contained areas of adenocarcinoma. After surgical excision followed by radiation therapy, there was no recurrence after two and five years, respectively.

The histological and immunohistochemical findings support the assumption that these two tumours are carcinosarcomas. Adenocarcinomatous elements in this type of tumour have to our kowledge been reported only twice previously and have never been observed in the pharynx.

Keywords

CarcinomaSarcomaCarcinosarcomaOropharynxHistologyImmunohistocheniistry
Type
Pathology in Focus
Information
The Journal of Laryngology & Otology , Volume 109 , Issue 5 , May 1995 , pp. 459 - 465
Copyright
Copyright © JLO (1984) Limited 1995

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