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Pre-treatment anaemia alters outcome in early squamous cell carcinoma of the larynx treated by radical radiotherapy

Published online by Cambridge University Press:  29 June 2007

D. G. Grant ,
A. Hussain  and
D. Hurman
D. G. Grant
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Aberdeen Royal Infirmary, Aberdeen, UK.
A. Hussain*
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Aberdeen Royal Infirmary, Aberdeen, UK.
D. Hurman
Affiliation:
Department of Radiotherapy and Oncology, Aberdeen Royal Infirmary, Aberdeen, UK.
*
Address for correspondence: Mr A. Hussain, F.R.C.S., Department of Otolaryngology-HNS, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN Fax: (01224) 840900
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Abstract

The purpose of this study was to examine the effect of pre-treatment anaemia on tumour recurrence and survival in patients treated with primary radiotherapy for early squamous cell carcinoma of the larynx. A retrospective analysis of 117 patients with previously untreated T1N0M0 and T2N0M0 squamous cell carcinoma of the larynx was carried out. Patients were considered anaemic if their pre-treatment haemoglobin levels were below 13 g/dl in males and 11.5 g/dl in females. The influence of pre-treatment haemoglobin levels on local control and survival were evaluated using Cox proportional hazards regression models.

Two- and five-year local-regional control estimates for anaemic patients were 58 per cent and 53 per cent respectively while patients with normal haemoglobin levels had two and five-year local-regional control rates of 90 per cent and 81 per cent respectively (p = 0.002). Multivariate Cox regression analysis showed pre-treatment haemoglobin significantly influencing recurrence-free survival (p = 0.0094).

Patients with a low haemoglobin level prior to radiation therapy suffered higher levels of local-regional failure.

Keywords

LarynxCarcinoma, squamous cellRadiotherapyAnaemiaOutcome assessment
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 113 , Issue 9 , September 1999 , pp. 829 - 833
Copyright
Copyright © JLO (1984) Limited 1999

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