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Primary small cell carcinoma of lacrimal sac: case report and literature review

Published online by Cambridge University Press:  23 April 2010

T Goto ,
N Bandoh ,
T Nagato ,
M Takahara ,
Y Harabuchi ,
Y Tokusashi  and
N Miyokawa
T Goto
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical College, Obihiro, Japan Head and Neck Cancer Center, Hokuto Hospital, Obihiro, Japan
N Bandoh*
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical College, Obihiro, Japan Head and Neck Cancer Center, Hokuto Hospital, Obihiro, Japan
T Nagato
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical College, Obihiro, Japan
M Takahara
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical College, Obihiro, Japan
Y Harabuchi
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical College, Obihiro, Japan
Y Tokusashi
Affiliation:
Department of Surgical Pathology, Asahikawa Medical College, Obihiro, Japan
N Miyokawa
Affiliation:
Department of Surgical Pathology, Asahikawa Medical College, Obihiro, Japan
*
Address for correspondence: Dr Nobuyuki Bandoh, Head and Neck Cancer Center, Hokuto Hospital, Inadacho Kisen 7-5, Obihiro, Hokkaido, 080-0833, Japan. Fax: +81 155 47 3094 E-mail: bando@hokuto7.or.jp
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Abstract

Objective:

We present the first reported case of primary small cell carcinoma of the lacrimal sac.

Case report:

A 67-year-old Japanese woman was referred to our department with a two-month history of left medial canthal swelling, epiphora and occasional nasal bleeding. Nasal endoscopy revealed a readily bleeding tumour in the left inferior meatus. Computed tomography and magnetic resonance imaging scans demonstrated that the tumour was mainly located in the left lacrimal sac. Histopathological studies of a biopsy specimen revealed small cell carcinoma. The patient was treated with four cycles of chemotherapy consisting of cisplatin and etoposide, in combination with radiotherapy. There was no evidence of recurrence or metastasis for five years.

Conclusion:

Small cell carcinoma originating in the head and neck region has been reported to be highly aggressive and to have a poor prognosis. We report a case of primary small cell carcinoma of the lacrimal sac successfully treated with chemo-radiotherapy.

Keywords

Small Cell CarcinomaLacrimal Sac
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 11 , November 2010 , pp. 1223 - 1226
Copyright
Copyright © JLO (1984) Limited 2010

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