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Quantitative analysis of tegmen bone mineral density in obese and non-obese patients

Published online by Cambridge University Press:  01 October 2021

S Holmes ,
A Geimadi ,
A Mamilly ,
M Hamiter ,
H Cuellar  and
G Mankekar
S Holmes*
Affiliation:
Department of Otolaryngology, Ochsner Louisiana State University (‘LSU’) Health Shreveport, Shreveport, USA
A Geimadi
Affiliation:
Department of Radiology, Ochsner Louisiana State University (‘LSU’) Health Shreveport, Shreveport, USA
A Mamilly
Affiliation:
Department of Radiology, Ochsner Louisiana State University (‘LSU’) Health Shreveport, Shreveport, USA
M Hamiter
Affiliation:
Department of Otolaryngology, Ochsner Louisiana State University (‘LSU’) Health Shreveport, Shreveport, USA
H Cuellar
Affiliation:
Department of Radiology, Ochsner Louisiana State University (‘LSU’) Health Shreveport, Shreveport, USA
G Mankekar
Affiliation:
Department of Otolaryngology, Ochsner Louisiana State University (‘LSU’) Health Shreveport, Shreveport, USA
*
Author for correspondence: Dr Sean Holmes, 952 Elmwood St, Shreveport, Louisiana71104, USA E-mail: sholm6@lsuhsc.edu
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Abstract

Background

Certain factors have been linked to lateral skull base demineralisation or erosion, which may predispose to spontaneous cerebrospinal fluid leak. There are relatively few quantitative reports of skull base changes in patient populations.

Method

A novel refined measurement algorithm for quantification of tegmen bone mineral density was developed, and bone mineral density between obese and non-obese patient groups was compared. Computed tomography scans were analysed by three blinded reviewers, and tegmen bone mineral densities were compared.

Results

There were 23 patients in the obese group and 27 matched controls in the non-obese group. Inter-rater reliability was ‘strong’ to ‘near complete’ (κ = 0.75–0.86). No differences in tegmen bone mineral density were found between the groups (p = 0.64). The number of active blood pressure medications correlated positively with lateral skull base bone mineral density.

Conclusion

A novel, refined, quantitative measurement algorithm for the assessment of tegmen bone mineral density was developed and validated. Obesity was not found to significantly affect tegmen bone mineral density.

Keywords

Temporal BoneSkull BaseObesityBlood PressureEncephalocelePseudotumor Cerebri
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 135 , Issue 12 , December 2021 , pp. 1075 - 1080
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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Footnotes

Dr S Holmes takes responsibility for the integrity of the content of the paper

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