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Recurrent squamous cell carcinoma in the neopharynx treated successfully with topical 5-fluorouracil

Published online by Cambridge University Press:  08 March 2006

Rupan Banga ,
James Ramsden  and
Graham Cox
Rupan Banga
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Radcliffe Infirmary, Oxford, UK.
James Ramsden
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Radcliffe Infirmary, Oxford, UK.
Graham Cox
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Radcliffe Infirmary, Oxford, UK.
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Abstract

We present the first reported case of a squamous cell carcinoma recurrence on a reconstructed flap in the pharynx treated successfully with topical chemotherapy. The patient, treated for a pharyngeal cancer with resection and reconstruction with a free radial forearm flap, and post-operative radiotherapy, developed a tumour on the flap more than two years after surgery. The recurrence was also squamous carcinoma, but there was only superficial infiltration. This was treated with 5-fluorouracil paste placed in the pharynx, with resolution of thetumour. The patient was alive and well more than 28 months after this treatment, with no sign of disease recurrence. Topical chemotherapy for treatment of oral cancer is well described for early disease, but we show that it may be a useful treatment in recurrent disease in selected patients.

Keywords

Head and Neck NeoplasmsPharynxCarcinomaFluorourocil
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 119 , Issue 5 , May 2005 , pp. 403 - 404
Copyright
© 2005 Royal Society of Medicine Press

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