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Rhabdomyosarcoma of the adult head and neck: a clinicopathological and DNA ploidy study

Published online by Cambridge University Press:  29 June 2007

Adel K. El-Naggar ,
John G. Batsakis ,
Nelson G. Ordónez ,
Mario A. Luna  and
Helmuth Goepfert
Adel K. El-Naggar*
Affiliation:
Deparments of Pathology, the University of Texas, M. D. Anderson Cancer Center, Houston Texas
John G. Batsakis
Affiliation:
Deparments of Pathology, the University of Texas, M. D. Anderson Cancer Center, Houston Texas
Nelson G. Ordónez
Affiliation:
Deparments of Pathology, the University of Texas, M. D. Anderson Cancer Center, Houston Texas
Mario A. Luna
Affiliation:
Deparments of Pathology, the University of Texas, M. D. Anderson Cancer Center, Houston Texas
Helmuth Goepfert
Affiliation:
Deparments of Pathology, the University of Texas, M. D. Anderson Cancer Center, Houston Texas
*
Adel K. El-Naggar, M. D., Department of Pathology, The University of Texas, M. D. Anderson Cancer Center, Box 85, 1515 Holcombe Blvd., Houston, Texas 77030.
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Abstarct

We investigated the DNA ploidy patten in thirteen primary and four recurrent rhabdomyosarcomas of teh head and neck from thirteen adult patients and conrrelated the findings with other clinicopathological factors and clinical outcome. Twelve (92.7 per cent) of the primary neoplasms manifested an aneuploid DNA pattern. All recurrent lesions were DNA aneuploid with DNA indices (DIs) Corresponding to their primary neoplasms. No correlation beteween the ploidy pattern and histological subtypes, tumours location, clinical stage and patient's clinical course was found. In this study, only two patients were long-term, survivors. Both patients had stage I neoplasms that were located in non-parameninigeal sites which manifested an alvellar histological pattern. Our data indicate that adult rhabdoyosarcomas of adult and neck are preponderantly DNA aneuploid and are highly aggressive malignant neoplasms. Our results alson suggest that tumours which are low stage and in a non-parameningeal location may pursue a less aggressive course.

Keywords

RhabdomysarcomaFlow cytometryDNA
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 107 , Issue 8 , August 1993 , pp. 716 - 720
Copyright
Copyright © JLO (1984) Limited 1993

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