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Serum adenosine deaminase and total superoxide dismutase activities before and after surgical removal of cancerous laryngeal tissue

Published online by Cambridge University Press:  29 June 2007

Orhan Canbolat ,
Ömer Akyol ,
Mustafa Kavutcu ,
A. Ümit Isik  and
Ilker Durak
Orhan Canbolat
Affiliation:
Ankara University Medical Faculty, Department of Biochemistry, Ankara, Turkey
Ömer Akyol
Affiliation:
Ankara University Medical Faculty, Department of Biochemistry, Ankara, Turkey
Mustafa Kavutcu
Affiliation:
Ankara University Medical Faculty, Department of Biochemistry, Ankara, Turkey
A. Ümit Isik
Affiliation:
Ankara Numune Hospital, Ankara, Turkey
Ilker Durak*
Affiliation:
Ankara University Medical Faculty, Department of Biochemistry, Ankara, Turkey
*
Dr Ilker Durak, Ankara Üniversitesi Tip fakültesi, Biyokimya Anabilim Dali (Dekanlik Binasi), 06100-Sihhiye, Ankara, Turkiye
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Abstract

In this study, pre- and post-operative serum activities of adenosine deaminase (ADA) and total superoxide dismutase (SOD) enzymes were measured in patients with squamous cell laryngeal cancer. Activities of both enzymes were found to be higher in cancerous patients compared to the controls. No significant differences were found however between pre- and post-operative values for both enzymes in the patient group.

It has been suggested that ADA and SOD enzymes leak from the cancerous laryngeal tissues into the blood stream. The absence of differences between pre- and post-operative serum enzyme activities has two possible explanations: Firstly, removal of previously released enzymes from the blood stream takes a much longer period than one month; and secondly, cancerous laryngeal tissue is not the only source of the enzymes mentioned even after removal of cancerous tissue by surgical operation, other sources such as adjacent tissues and/or metastatic tissues etc, still release these enzymes into the blood stream.

Keywords

Adenosine deaminaseSuperoxide dismutaseLaryngeal neoplasmscarcinoma
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 108 , Issue 10 , October 1994 , pp. 849 - 851
Copyright
Copyright © JLO (1984) Limited 1994

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