Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-11T10:33:03.540Z Has data issue: false hasContentIssue false
  • English
  • Français

Serum antibodies against respiratory tract viruses in episodes of acute otitis media

Published online by Cambridge University Press:  29 June 2007

Göran Harsten ,
Karin Prellner ,
Bengt Löfgren  and
Olof Kalm
Göran Harsten*
Affiliation:
Departments of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden.
Karin Prellner
Affiliation:
Departments of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden.
Bengt Löfgren
Affiliation:
Departments of Oto-Rhino-Laryngology and Medical Microbiology, University Hospital, Lund, Sweden.
Olof Kalm
Affiliation:
Departments of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden.
*
Göran Harsten, M.D., Ph.D., Department of Oto-Rhino-Laryngology, University Hospital, S-221 85 Lund, Sweden.
Get access Rights & Permissions [Opens in a new window]

Abstract

Although the findings of epidemiological studies have suggested viral respiratory tract infection (RTI) to be crucially involved in the development of acute otitis media (AOM), the relationship between AOM and viral RTI remains unclear. Serum samples, obtained in the acute and convalescent phases of 57 AOM episodes (in 35 children during the first three years of life) were analysed for IgG antibodies against influenza A viruses, influenza B viruses, parainfluenza virus type 1, respiratory syncytial virus and adenoviruses.

One third of the AOM episodes (18/57) could be related to viral RTI, as evidenced by significant increases in viral serum antibody activity. Treatment failure occurred in four AOM episodes where increases in serum viral antibody activity were noted. In three of these failures, antibiotic treatment was unsuccessful despite the bacterial strains not being resistant to the drug used. This suggests that concomitant viral infection may be a determinant of treatment outcome in some AOM episodes.

Keywords

Otitis media, acuteAntibodiesVirus, respiratory tract
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 105 , Issue 5 , May 1991 , pp. 337 - 340
Copyright
Copyright © JLO (1984) Limited 1991

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Arola, M., Ziegler, T., Ruuskanen, O., Mertsola, J., Nanto-Salonen, K., Halonen, P. (1988) Rhinovirus in acute otitis media. Journal of Pediatrics, 113: 693–695.CrossRefGoogle ScholarPubMed
Arola, M., Ziegler, T., Ruuskanen, O. (1990) Respiratory virus infection as a cause of prolonged symptoms in acute otitis media. Journal of Pediatrics, 116: 697–701.CrossRefGoogle ScholarPubMed
Blomberg, J., Nilsson, I., Andersson, M. (1983) Viral antibody screening system that uses a standardized single dilution immunoglobulin G enzyme immunoassay with multiple antigens. Journal of Clinical Microbiology, 17: 1081–1091.CrossRefGoogle ScholarPubMed
Chonmaitree, T., Howie, V. M., Truant, A. L. (1986) Presence of respiratory viruses in middle ear fluids and nasal wash specimens from children with acute otitis media. Pediatrics, 77: 798–702.CrossRefGoogle ScholarPubMed
Giebink, G. S., Berzins, I. K., Marker, S. C., Schiffman, G. (1980) Experimental otitis media after nasal inoculation of Streptococcus pneumoniae and influenza A virus in chinchillas. Infection and Immunity, 30: 445–450.CrossRefGoogle ScholarPubMed
Harsten, G., Prellner, K., Heldrup, J., Kalm, O., Kornfalt, R. (1989a) Recurrent acute otitis media. A prospective study of children during the first three years of life. Acta Otolaryngologica, 107: 111–119.CrossRefGoogle ScholarPubMed
Harsten, G., Prellner, K., Heldrup, J., Kalm, O., Kornfalt, R. (1989b) Treatment failure in acute otitis media. A clinical study of children during their first three years of life. Acta Otolaryngologica, 108: 253–258.CrossRefGoogle ScholarPubMed
Harsten, G., Prellner, K., Lofgren, B., Heldrup, J., Kalm, O., Kornfalt, R. (1989c) Serum antibodies against respiratory tract viruses: A prospective three-year follow-up from birth. Journal of Laryngology and Otology, 103: 904–908.CrossRefGoogle ScholarPubMed
Heikkinen, T., Ruuskanen, O., Waris, M., Ziegler, T., Arola, M., Halonen, P. (1989) Influenza vaccination in the prevention of acute otitis media. In: Conference on the Eustachian tube and middle ear diseasesGeneva, SwitzerlandOctober 26–29, 1989. Book of Program and Abstracts, p. 56.Google Scholar
Henderson, F. W., Collier, A. M., Sanyal, M. A., Watkins, J. M., Fairclough, D. L., Clyde, W. A. Jr, Denny, F. W. (1982) A longitudinal study of respiratory viruses and bacteria in the etiology of acute otitis media with effusion. New England Journal of Medicine, 306: 1377–1383.CrossRefGoogle ScholarPubMed
Klein, B. S., Dollete, F. R., Yolken, R. H. (1982) The role of respiratory syncytial virus and other viral pathogens in acute otitis media. Journal of Pediatrics, 101: 16–20.CrossRefGoogle ScholarPubMed
Marchant, C. D., Shurin, P. A. (1983) Therapy of otitis media. Pediatric Clinics of North America, 30: 281–296.CrossRefGoogle ScholarPubMed
McBride, T. P., Doyle, W. J., Hayden, F. G., Gwaltney, J. M. Jr (1989) Alterations of the eustachian tube, middle ear, and nose in rhinovirus infection. Archives of Otolaryngology Head and Neck Surgery, 115: 1054–1059.CrossRefGoogle ScholarPubMed
Pukander, J., Karma, P., Sipila, M. (1982) Occurrence and recurrence of acute otitis media among the children. Acta Otolaryngologica, 94: 479–486.CrossRefGoogle Scholar
Ruuskanen, O., Arola, M., Putto-Laurila, A., Mertsola, J., Meurman, O., Viljanen, M. K., Halonen, P. (1989) Acute otitis media and respiratory virus infections. Pediatric Infectious Disease Journal, 8: 94–99.Google ScholarPubMed
Sarkkinen, H., Ruuskanen, O., Meurman, O., Puhakka, H., Virolainen, E., Eskola, J. (1985) Identification of respiratory virus antigens in middle ear fluids of children with acute otitis media. Journal of Infectious Diseases, 151: 444–448.CrossRefGoogle ScholarPubMed
Stenstrom, C., Ingvarsson, L. (1988) General illness among otitis prone and ordinary children. In: Proceedings of the Fourth International Symposium on Recent Advances in Otitis Media (Lim, D. J., Bluestone, C. D., Klein, J. O. and Nelson, J. D., eds.), B. C. Decker Inc: Toronto, Philadelphia, p. 11–13.Google Scholar
Teele, D. W., Klein, J. O., Rosner, B. and the Greater Boston Otitis Media Study Group. (1989) Epidemiology of otitis media during the first seven years of life in children in Greater Boston: a prospective, cohort study. Journal of Infectious Diseases, 160: 83–94.CrossRefGoogle ScholarPubMed
Tilles, J. G., Klein, J. O., Jao, R. L., Haslam, J. E. Jr, Feingold, M., Gellis, S. S., Finland, M. (1967) Acute otitis media in children. Serologic studies and attempts to isolate viruses and mycoplasmas from aspirated middle-ear fluids. New England Journal of Medicine, 111: 613–618.CrossRefGoogle Scholar