Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-10T12:25:28.301Z Has data issue: false hasContentIssue false
  • English
  • Français

Serum leucine aminopeptidase in head and neck cancer

Published online by Cambridge University Press:  29 June 2007

L. N. Garg ,
S. P. S. Yadav  and
Harbans Lal
L. N. Garg
Affiliation:
Departments of Otolaryngology, Medical College and Hospital, Rohtak-124001, India
S. P. S. Yadav
Affiliation:
Departments of Otolaryngology, Medical College and Hospital, Rohtak-124001, India
Harbans Lal*
Affiliation:
Departments of Biochemistry, Medical College and Hospital, Rohtak-124001, India
*
Dr Harbans Lal, Associate Professor Biochemistry, 15/8FM, Medical College, Rohtak-124001, India..
Get access Rights & Permissions [Opens in a new window]

Abstract

Serum leucine aminopeptidase (LAP) activity was assayed in patients with head and neck cancer. The levels were found to be significantly higher than the controls. However, the rise in serum LAP was nearly the same in all the patients studied, irrespective of the character or histopathology of the lesion but varied with respect to the site involved, i.e. from about 40 per cent in cancer of the hypopharynx to more than 100 per cent in cancer of the nasopharynx. Serum LAP activity was found to increase with the extent of the lymph node spread. After treatment the levels were found to be reduced.

Keywords

Leucine aminopeptidaseNeoplasm stagingNeoplasm metastasisLymph nodesHead and neck neoplasms
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 108 , Issue 8 , August 1994 , pp. 660 - 662
Copyright
Copyright © JLO (1984) Limited 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Aziz, M., Gupta, S. K., Khan, A. A., Saluddin, A. (1988) Prognostic evaluation of serum leucine aminopeptidase in malignancy of lymphoreticular and haemopoietic cell lines in children with special reference to malignant histiocytosis of the intestine. Journal of Tropical Pediatrics 34: 65–70.CrossRefGoogle ScholarPubMed
Gupta, S. K., Aziz, M., Khan, A. A. (1989) Serum leucine aminopeptidase estimation: a sensitive prognostic indicator of invasiveness in breast carcinoma. Indian Journal of Pathology and Microbiology 32: 301–305.Google Scholar
Martinek, R. G., Berger, L., Broida, D. (1964) Simplified estimation of leucine aminopeptidase (LAP) activity. Clinical Chemistry 10: 1087–1097.Google Scholar
Mehrotra, T. N., Singh, V. S., Mital, H. S., Bahadur, V., Singh, R. (1984) Leucine aminopeptidase in gastrointestinal cancers. Journal of the Association of Physicians of India 32: 583–584.Google Scholar
Nagaoka, I., Yamashita, T. (1983) Possible exposure of LAP on the cell surface of rabbit blood neutrophils by digitonin treatment. Biochimica et Biophysica Acta 804: 176–180.Google Scholar
Phillips, R. W., Manildi, E. R. (1970) Elevation of leucine aminopeptidase in disseminated malignant disease. Cancer 26: 1006–1012.Google Scholar
Pineda, E. P., Goldberg, J. A., Banks, B. M., Rutenburg, A. M. (1960) Serum leucine aminopeptidase in pancreatic and hepatobiliary disease. Gastroenterology 38: 698–712.Google Scholar
Pruzanski, W., Fischl, J. (1964) The evaluation of serum leucine aminopeptidase estimation. American Journal of Medical Sciences 248: 581–587.Google Scholar
Smith, E. L., Hill, R. L. (1960) Leucine aminopeptidase. In The Enzymes. Vol. 4. (Boyer, P. D., Landy, H., Myrbek, K. K., eds.) Academic Press, New York, pp 37–62.Google Scholar