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Serum otolin-1 as a biomarker for benign paroxysmal positional vertigo: a case-control study

Published online by Cambridge University Press:  17 June 2021

D V K Irugu ,
A Singh ,
H Yadav ,
H Verma ,
R Kumar ,
R A Abraham  and
L Ramakrishnan
D V K Irugu*
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India
A Singh
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India
H Yadav
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India
H Verma
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India
R Kumar
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India
R A Abraham
Affiliation:
Department of Cardiac Biochemistry, All India Institute of Medical Sciences, New Delhi, India
L Ramakrishnan
Affiliation:
Department of Cardiac Biochemistry, All India Institute of Medical Sciences, New Delhi, India
*
Author for correspondence: Dr David Victor Kumar Irugu, Room No. 4057, ENT Office, 4th Floor, Teaching Block, All India Institute of Medical Sciences, New Delhi110029, India E-mail: dvki2016@gmail.com
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Abstract

Objectives

This study aimed to evaluate serum otolin-1 levels in patients with benign paroxysmal positional vertigo and to compare these levels with healthy individuals.

Method

This was a case-control study. After obtaining institutional ethical committee clearance, the serum level of otolin-1 was calculated in adult individuals (18–75 years old) who were divided into group 1 (patients presenting with benign paroxysmal positional vertigo) and group 2 (healthy patients without benign paroxysmal positional vertigo as the control group). Data analysis was carried out to compare the serum levels in the cases and controls. A p-value less than 0.05 was considered significant.

Results

A total of 70 age-matched individuals (cases, n = 40; controls, n = 30) were included in the study. The mean serum level of otolin-1 was 636.8 pg/ml (range, 259–981 pg/ml) in the group of patients with benign paroxysmal positional vertigo and 236.2 pg/ml (range, 189–370 pg/ml) in the control group. The difference was statistically significant (p = 0.0000).

Conclusion

The serum levels of otolin-1 in patients with benign paroxysmal positional vertigo are significantly higher compared with individuals without benign paroxysmal positional vertigo.

Keywords

Benign Paroxysmal Positional VertigoBiomarkerOtolithic MembraneSemicircular Canals
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 135 , Issue 7 , July 2021 , pp. 589 - 592
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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Footnotes

Dr D V K Irugu takes responsibility for the integrity of the content of the paper

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