Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-11T16:11:21.903Z Has data issue: false hasContentIssue false
  • English
  • Français

Sinonasal mucosal melanoma: retrospective survival study of 25 patients

Published online by Cambridge University Press:  29 September 2011

C Vandenhende ,
X Leroy ,
D Chevalier  and
G Mortuaire
C Vandenhende
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Huriez Hospital, University of Lille, France
X Leroy
Affiliation:
Department of Pathology, Huriez Hospital, University of Lille, France
D Chevalier
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Huriez Hospital, University of Lille, France
G Mortuaire*
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Huriez Hospital, University of Lille, France
*
Address for correspondence: Dr Geoffrey Mortuaire, Service d'ORL de Chirurgie Cervico-faciale, Pr Chevalier, CHRU Lille, 59000, France Fax: +33 320446220 E-mail: g-mortuaire@chru-lille.fr
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

To determine potential prognostic factors for survival in patients with mucosal malignant melanoma of the sinonasal tract.

Methods:

Patients managed between 1991 and 2008 were assessed retrospectively. The seventh edition Union for International Cancer Control (7th UICC) tumour-node-metastasis classification was used for tumour staging. Kaplan–Meier and log rank tests were used for survival analysis.

Results:

Twenty-five patients were studied (six were tumour stage three, eight tumour stage four(a) and 11 tumour stage four(b)). Surgery was performed on 23 patients (92 per cent). Fifteen received post-operative radiotherapy. Mean follow up was 31.3 months (range, two to 99 months). Three-year disease-free survival was improved in patients with stage four tumour arising from the nasal fossa, versus other sites, and in those with stage four tumour treated with surgery plus adjuvant radiotherapy, versus other treatments.

Conclusion:

Patients with melanoma of the nasal cavity have very poor survival rates. Treatment is still based on adequate surgical resection with safe margins. In this study, post-operative radiotherapy improved local control only for stage four tumours.

Keywords

Nasal CavityParanasal SinusesMalignant MelanomaPrognosis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 2 , February 2012 , pp. 147 - 151
Copyright
Copyright © JLO (1984) Limited 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Enée, V, Houliat, T, Truilhé, Y, Darrouzet V, Stoll D. Malignant melanoma of the nasosinal mucosa [in French]. Retrospective study a propos of 20 cases. Rev Laryngol Otol Rhinol (Bord) 2000;121:243–50Google ScholarPubMed
2Huang, SF, Liao, CT, Kan, CR, Chen, IH. Primary mucosal melanoma of the nasal cavity and paranasal sinuses: 12 years of experience. J Otolaryngol 2007;36:124–9CrossRefGoogle ScholarPubMed
3Ganly, I, Patel, SG, Singh, B, Kraus, DH, Bridger, PG, Cantu, G et al. Craniofacial resection for malignant melanoma of the skull base: report of an international collaborative study. Arch Otolaryngol Head Neck Surg 2006;132:73–8CrossRefGoogle ScholarPubMed
4Bhattacharyya, N. Cancer of the nasal cavity: survival and factors influencing prognosis. Arch Otolaryngol Head Neck Surg 2002;128:1079–83CrossRefGoogle ScholarPubMed
5Owens, JM, Roberts, DB, Myers, JN. The role of postoperative adjuvant radiation therapy in the treatment of mucosal melanomas of the head and neck region. Arch Otolaryngol Head Neck Surg 2003;129:864–8CrossRefGoogle ScholarPubMed
6Prasad, ML, Busam, KJ, Patel, SG, Hoshaw-Woodard, S, Shah, JP, Huvos, AG. Clinicopathologic differences in malignant melanoma arising in oral squamous and sinonasal respiratory mucosa of the upper aerodigestive tract. Arch Pathol Lab Med 2003;127:997–1002CrossRefGoogle ScholarPubMed
7Lee, SP, Shimizu, KT, Tran, LM, Juillard, G, Calcaterra, TC. Mucosal melanoma of the head and neck: the impact of local control on survival. Laryngoscope 1994;104:121–6CrossRefGoogle ScholarPubMed
8Pomar Blanco, P, San Román Carbajo, J, Bouso Montero, M, Martín Villares, C, Fernández Pello, M, Tapia Risueño, M. Sinonasal mucosal melanoma [in Spanish]. An Otorrinolaringol Ibero Am 2007;34:349–58Google ScholarPubMed
9Trapp, TK, Fu, YS, Calcaterra, TC. Melanoma of the nasal and paranasal sinus mucosa. Arch Otolaryngol Head Neck Surg 1987;113:1086–9CrossRefGoogle ScholarPubMed
10Dauer, EH, Lewis, JE, Rohlinger, AL, Weaver, AL, Olsen, KD. Sinonasal melanoma: a clinicopathologic review of 61 cases. Otolaryngol Head Neck Surg 2008;138:347–52CrossRefGoogle ScholarPubMed
11Meleti, M, Leemans, CR, de Bree, R, Vescovi, P, Sesenna, E, van der Waal, I. Head and neck mucosal melanoma: experience with 42 patients, with emphasis on the role of postoperative radiotherapy. Head Neck 2008;30:1543–51Google ScholarPubMed
12Temam, S, Mamelle, G, Marandas, P, Wibault, P, Avril, MF, Janot, F et al. Postoperative radiotherapy for primary mucosal melanoma of the head and neck. Cancer 2005;103:313–19CrossRefGoogle ScholarPubMed
13Stárek, I, Koranda, P, Benes, P. Sentinel lymph node biopsy: a new perspective in head and neck mucosal melanoma? Melanoma Res 2006;16:423–7CrossRefGoogle ScholarPubMed
14Lund, VJ, Howard, DJ, Harding, L, Wei, WI. Management options and survival in malignant melanoma of the sinonasal mucosa. Laryngoscope 1999;109:208–11Google ScholarPubMed
15Mendenhall, WM, Amdur, RJ, Hinerman, RW, Werning, JW, Villaret, DB, Mendenhall, NP. Head and neck mucosal melanoma. Am J Clin Oncol 2005;28:626–30CrossRefGoogle ScholarPubMed
16Wu, AJ, Gomez, J, Zhung, JE, Chan, K, Gomez, DR, Wolden, SL et al. Radiotherapy after surgical resection for head and neck mucosal melanoma. Am J Clin Oncol 2010;33:281–5CrossRefGoogle ScholarPubMed
17Wagner, M, Morris, CG, Werning, JW, Mendenhall, WM. Mucosal melanoma of the head and neck. Am J Clin Oncol 2008;31:43–8CrossRefGoogle ScholarPubMed