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Sodium fluoride in otosclerosis treatment: review

Published online by Cambridge University Press:  18 February 2010

A S Cruise*
Affiliation:
Department of Otolaryngology, Royal Free Hospital, London, UK
A Singh
Affiliation:
Department of Otolaryngology, Royal Free Hospital, London, UK
R E Quiney
Affiliation:
Department of Otolaryngology, Royal Free Hospital, London, UK
*
Address for correspondence: Mr A S Cruise, Department of Otolaryngology, Royal Free Hospital, 330 Gray's Inn Road, London WC1X 8DA, UK. Fax: 0207915 1430 E-mail: mr.andrew.cruise@gmail.com

Abstract

Objectives:

To review the current literature on the use of sodium fluoride in the treatment of otosclerosis.

Design:

A literature review was conducted, searching the Medline and PubMed database from 1966 to 2009, using the terms ‘otosclerosis’ and ‘fluoride’. Article abstracts were reviewed and relevant full articles acquired.

Results:

There has been only one double-blind, placebo-controlled trial of the use of sodium fluoride in otosclerosis patients, and this found a reduced incidence of deterioration in hearing after two years in the treatment group. Several case–control series have described a hearing benefit in the sodium fluoride treated group. Treatment doses vary greatly, and there is no evidence regarding the optimum duration of treatment.

Conclusions:

There is low quality evidence suggesting that sodium fluoride may be of benefit to preserve hearing and reduce vestibular symptoms in patients with otosclerosis.

Type
Review Articles
Copyright
Copyright © JLO (1984) Limited 2010

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