Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-28T05:15:43.440Z Has data issue: false hasContentIssue false
  • English
  • Français

Solubilization of keratin debris in conservative treatment of middle ear cholesteatoma: an in vitro study

Published online by Cambridge University Press:  29 June 2007

Kiyofumi Gyo  and
Yasushi Sasaki
Kiyofumi Gyo*
Affiliation:
Department of Otolaryngology, Ehime University School of Medicine, Shigenobu-cho, Ehime, Japan.
Yasushi Sasaki
Affiliation:
Department of Otolaryngology, Ehime University School of Medicine, Shigenobu-cho, Ehime, Japan.
*
Kiyofumi Gyo, M.D., Department of Otolaryngology, Ehime University School of Medicine, Shigenobu-cho, Ehime, Japan 791-02. Fax: Japan 0899-64-5236
Get access Rights & Permissions [Opens in a new window]

Abstract

A variety of solutions were tested in vitro to find a suitable solvent which could be used in clinical practice for cholesteatoma debris. Though a little weak as a solvent, a liquid soap composed mainly of plant oil did not cause irritation of the middle ear mucosa, and was thought to be a promising solvent with which to rinse away tenacious debris, especially when used in combination with hydrogen peroxide.

Keywords

Cholesteatoma
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 108 , Issue 2 , February 1994 , pp. 113 - 115
Copyright
Copyright © JLO (1984) Limited 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Georgopoulos, G. N. (1989) Late results of conservative treatment of some cases of cholesteatomatous otitis. In Cholesteatoma and Mastoid Surgery. (Tos, M., Thomsen, J., Peitersen, E., eds.), Kugler and Ghedini Publications, Amsterdam/Berkeley/Milan, pp 745–748.Google Scholar
Goodhill, V. (1979) Chronic otomastoiditis-diagnosis and management. In Ear Diseases, Deafness and Dizziness. (Goodhill, V., ed.), Harper and Row Publications, Hagerstown, pp 330–354.Google Scholar
Ilino, Y., Hoshino, E., Tomioka, S., Takasaka, T., Kaneko, Y., Yuasa, R. (1982) The organic acids and anaerobic microorganisms in the contents of the cholesteatoma sac. Annals of Otology, Rhinology and Laryngology 92: 91–96.Google Scholar
Kluyskens, P., Gillis, E., Nsabumukunzi, S. (1979) First observations on treatment of cholesteatoma with N-acetylcysteine. Acta Otolaryngology 87: 362–365.CrossRefGoogle ScholarPubMed
Kluyskens, P., Gillis, E., Broekaert, D., Coucke, P., Nsabumukunzi, S., Reyniers, P. (1981) Further research on solubilization of cholesteatoma keratins. Acta Otolaryngology 91: 585–587.CrossRefGoogle ScholarPubMed
Lehninger, A. L. (1975) Protein: three dimensional conformation, the keratin. In Biochemistry. 2nd Edition. Worth Publishers Inc., New York, pp 126–135.Google Scholar
Orisk, B. S., Chole, R. A. (1987) Pressure exerted by experimental cholesteatoma. Archives of Otolaryngology 113: 386–391.CrossRefGoogle Scholar
Ruedi, I. (1957) The pathogenesis and treatment of cholesteatoma in chronic suppuration of the temporal bone. Annals of Otology, Rhinology and Laryngology 66: 283–294.CrossRefGoogle ScholarPubMed