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Sudden presentation of immune-mediated inner ear disease: characterization and acceptance of a cochleovestibular dysfunction

Published online by Cambridge University Press:  08 March 2006

José Ramón García-Berrocal ,
Rafael Ramírez-Camacho ,
Isabel Millán ,
Carmen Górriz ,
Almudena Trinidad ,
Beatriz Arellano  and
David Lobo
José Ramón García-Berrocal
Affiliation:
Service of Otorhinolaryngology, Clinica Puerta de Hierro Hospital, Department of Surgery, Faculty of Medicine, Autónoma University; Madrid, Spain.
Rafael Ramírez-Camacho
Affiliation:
Service of Otorhinolaryngology, Clinica Puerta de Hierro Hospital, Department of Surgery, Faculty of Medicine, Autónoma University; Madrid, Spain.
Isabel Millán
Affiliation:
Statistical Department, Clinica Puerta de Hierro Hospital, Department of Surgery, Faculty of Medicine, Autónoma University; Madrid, Spain.
Carmen Górriz
Affiliation:
Service of Otorhinolaryngology, Clinica Puerta de Hierro Hospital, Department of Surgery, Faculty of Medicine, Autónoma University; Madrid, Spain.
Almudena Trinidad
Affiliation:
Service of Otorhinolaryngology, Clinica Puerta de Hierro Hospital, Department of Surgery, Faculty of Medicine, Autónoma University; Madrid, Spain.
Beatriz Arellano
Affiliation:
Service of Otorhinolaryngology, Clinica Puerta de Hierro Hospital, Department of Surgery, Faculty of Medicine, Autónoma University; Madrid, Spain.
David Lobo
Affiliation:
Service of Otorhinolaryngology, Clinica Puerta de Hierro Hospital, Department of Surgery, Faculty of Medicine, Autónoma University; Madrid, Spain.
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Abstract

Since the McCabe report, growing indirect evidence has accumulated to indicate the implication of immune mechanisms in the pathogenesis of immune-mediated inner-ear disease (IMIED). A clinical study of a group of patients affected by this condition was performed in order to characterize the immune group, based on a recently reported profile, and compared with the vascular, viral and idiopathic aetiologies of sudden deafness. Patients affected by immune-mediated inner-ear disease had the best and the earliest recovery rate of hearing (p = 0.0028 and p = 0.017, respectively). However, this group of patients also had the higher rate of recurrence (p = 0.034), supporting the typical clinical course of the autoimmune disorders. On the basis of the results the criteria used in the diagnosis of the sudden presentation of the immune-mediated inner ear disease could be accepted leading to the characterization of this condition. Likewise, the role of the supporting cells in the pathogenesis of the IMIED is discussed.

Keywords

Hearing Loss SensorineuralImmune SystemPrednisoloneTreatment Outcome
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 117 , Issue 10 , October 2003 , pp. 775 - 779
Copyright
© Royal Society of Medicine Press Limited 2003

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