Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-27T22:08:24.781Z Has data issue: false hasContentIssue false
  • English
  • Français

Triple primary cancers of the head and neck: case report and literature review

Published online by Cambridge University Press:  22 May 2014

M Adams  and
R Caffrey
M Adams*
Affiliation:
Department of Otolaryngology/Head and Neck Surgery, Altnagelvin Area Hospital, Derry, Northern Ireland, UK
R Caffrey
Affiliation:
Department of Otolaryngology/Head and Neck Surgery, Altnagelvin Area Hospital, Derry, Northern Ireland, UK
*
Address for correspondence: Mr Mark Adams, 29 Manse Park, Carryduff, Belfast BT8 8RX, Northern Ireland, UK Fax: 0044 2890 634091 E-mail: jadams08@qub.ac.uk
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Coincident thyroid and head and neck squamous cell carcinomas are rare. This paper presents a case of synchronous laryngeal squamous cell carcinoma, follicular thyroid carcinoma and micropapillary thyroid carcinoma.

Methods:

A PubMed search was performed for articles describing synchronous thyroid and head and neck squamous cell carcinomas, using the search terms ‘thyroid cancer’, ‘cancer of the head and neck’, ‘synchronous’ and ‘synchronous neoplasm’.

Results:

The literature suggests that the head and neck squamous cell carcinoma stage is a better predictor of outcome than the extent of surgical treatment of the thyroid gland in synchronous malignancies.

Conclusion:

The decision regarding surgical treatment of the thyroid in synchronous thyroid and head and neck squamous cell carcinomas should take several factors into account. The head and neck squamous cell carcinoma stage is the strongest predictor of outcome, although patient-related factors and the location of malignant thyroid tissue may also affect management.

Keywords

Thyroid CancerHead And Neck NeoplasmsSynchronous Neoplasms
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 128 , Issue 6 , June 2014 , pp. 552 - 554
Copyright
Copyright © JLO (1984) Limited 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Yasuda, M, Kuwano, H, Watanabe, M, Toh, Y, Ohno, S, Sugimachi, K. P53 expression in squamous dysplasia associated with carcinoma of the oesophagus: evidence for field carcinogenesis. Br J Cancer 2000;83:1033–8Google Scholar
2Chu, PY, Chang, SY, Huang, JL, Tai, SK. Different patterns of second primary malignancy in patients with squamous cell carcinoma of larynx and hypopharynx. Am J Otolaryngol 2010;31:168–74CrossRefGoogle ScholarPubMed
3Pacheco-Ojeda, L, Michaeu, C, Luboinski, B, Richard, J, Travagli, JP, Schwaab, G et al. Squamous cell carcinoma of the upper aerodigestive tract associated with well differentiated carcinoma of the thyroid gland. Laryngoscope 1991;101:421–4Google Scholar
4Cupisti, K, Raffel, A, Ramp, U, Wolf, A, Donner, A, Krausch, M et al. Synchronous occurrence of a follicular, papillary and medullary thyroid carcinoma in a recurrent goitre. Endocr J 2005;52:281–5Google Scholar
5Ansari-Lari, M, Westra, WH. The prevalence and significance of clinically unsuspected neoplasms in cervical lymph nodes. Head Neck 2003;25:841–7Google Scholar
6Cheema, Y, Olson, S, Elson, D, Chen, H. What is the biology and optimal treatment for papillary microcarcinoma of the thyroid? J Surg Res 2006;134:160–2Google Scholar
7Gilbert, MR, Kim, S. Incidental thyroid cancer found during surgery for head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg 2012;147:647–53CrossRefGoogle ScholarPubMed
8Goepfet, H, Callender, DL. Differentiated thyroid cancer – papillary and follicular carcinomas. Am J Otolaryngol 1994;14:167–79Google Scholar
9Guzzo, M, Quattrone, P, Seregni, E, Bianchi, R, Mattavelli, F. Thyroid carcinoma associated with squamous cell carcinoma of the head and neck: which policy? Head Neck 2007;29:33–7CrossRefGoogle ScholarPubMed
10Brierly, J, Tsang, R, Panzarella, T, Bana, N. Prognostic factors and the effect of treatment with radioactive iodine and external beam radiation on patients with differentiated thyroid cancer seen at a single institution over 40 years. Clin Endocrinol 2005;63:418–27Google Scholar
11Ito, Y, Masuoka, H, Fukushima, M, Inoue, H, Kihara, M, Tomoda, C et al. Excellent prognosis of patients with solitary T1N0M0 papillary thyroid carcinoma who underwent thyroidectomy and elective lymph node dissection without radioiodine therapy. World J Surg 2010;34:1285–90Google Scholar
12Vassilopoulou-Sellin, R, Weber, RS. Metastatic thyroid cancer as an incidental finding during neck dissection: significance and management. Head Neck 1992;14:459–63CrossRefGoogle ScholarPubMed
13Farrag, T, Lin, F, Cummings, C, Sciubba, J, Koch, W, Flint, P et al. Importance of routine evaluation of the thyroid gland prior to open partial laryngectomy. Arch Otolaryngol Head Neck Surg 2006;132:1047–51Google Scholar