Hostname: page-component-cd9895bd7-p9bg8 Total loading time: 0 Render date: 2024-12-28T03:29:43.384Z Has data issue: false hasContentIssue false
  • English
  • Français

True carcinosarcoma of the larynx

Published online by Cambridge University Press:  29 June 2007

J. Klijanienko ,
P. Vielh ,
P. Duvillard  and
B. Luboinski
J. Klijanienko
Affiliation:
Histopathology A and B, 94805 Villejuif, France.
P. Vielh*
Affiliation:
Surgery Institut Gustave-Roussy, 94805 Villejuif, France.
P. Duvillard
Affiliation:
Histopathology A and B, 94805 Villejuif, France.
B. Luboinski
Affiliation:
Clinical Cytopathology, Institute Curie 75231 Paris, Cedex 05, France.
*
Docteur Philippe Vielh, Cytopathology Unit, Institute Curie, 26 rue d'Ulm, 75231 Paris Cedex 05, France.
Get access Rights & Permissions [Opens in a new window]

Abstract

A case of carcinosarcoma of the larynx and pyriform sinus with sarcomatous and epithelial malignant components is described in a 68-year-old male. The primary site was composed of spindle-shaped malignant mesenchymal cells with osteosarcomatous and chondrosarcomatous differentiation intermingled with areas of well differentiated squamous cell carcinoma, tubular and papillary adenocarcinoma, and trabecular neuroendocrine carcinoma. The metastatic lymph node showed squamous cell carcinoma and chondrosarcoma. Immunohistochemical studies showed that keratin was present in epithelial cells and negative in sarcoma, whereas vimentin and S-100 protein were present in sarcoma, but negative in carcinoma. Neuron-specific enolase was present in the neuroendocrine part of the tumour.

Keywords

Laryngeal neoplasmsCarcinosarcoma
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 1 , January 1992 , pp. 58 - 60
Copyright
Copyright © JLO (1984) Limited 1992

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Barnes, L. (1985) Surgical Pathology of the Head and Neck. Marcel Dekker, Inc., New York, Basel, p. 188.Google Scholar
Batsakis, J. G. (1974) Tumours of Head and Neck: Clinical and Pathological considerations. Second edition. Baltimore. Williams and Wilkins, p. 206.Google Scholar
Berean, K., Truong, L. D., Dudley, A. W., Cagle, P. T. (1988) Immunohistochemical characterization of pulmonary blastoma. American Journal of Clinical Pathology, 89: 773–777.CrossRefGoogle ScholarPubMed
Bergmann, M., Ackerman, L. V., Kemler, R. L. (1951) Carcinosarcoma of the lung. Review of the literature and report of two cases treated by pneumonectomy. Cancer, 4: 919–929.Google Scholar
Donaldson, I. (1978) Fibrosarcoma in a previously irradiated larynx. Journal of Laryngology and Otology, 92: 425–428.CrossRefGoogle Scholar
Hermanek, P., Sobin, L. H. (1988) TNM Classification of malignant tumours. Fourth edition. Springer Verlag, Geneve p. 26.Google Scholar
Holtz, F., Fox, J. E., Abell, M. R. (1972) Carcinosarcoma of the urinary bladder. Cancer, 29: 294–304.Google Scholar
Hutter, R. V. P., Foote, F. W., Francis, D. C. (1966) Primitive multipotential primary sarcoma of bone. Cancer, 19: 1–25.Google Scholar
Hyams, V. J., Batsakis, J. G., Michaels, L. (1988) Atlas of Tumour Pathology. Tumors of the upper respiratory tract. Fascicle 25, Armed Forces Institute of Pathology, Washington, p. 76.Google Scholar
Minckler, D. S., Meligro, C. H., Norris, H. T. (1970) Carcinosarcoma of the larynx. Case report with metastases of epidermoid and sarcomatous elements. Cancer, 26: 195–200.Google Scholar
Srinivasan, U., Talvalkar, G. V. (1979) The true carcinosarcoma of the larynx: A case report. Journal of Laryngology and Otology, 93: 1031–1035.CrossRefGoogle ScholarPubMed
Tobey, D. N., Wheelis, R. F., Yarington, C. T. Jr. (1979) Electron microscopy in the diagnosis of liposarcoma and fibrosarcoma of the larynx. Annals of Otology, Rhinology and Laryngology, 88: 867–871.Google Scholar
Wargotz, E. S., Norris, H. J. (1989) Metaplastic carcinomas of the breast. Carcinosarcoma. Cancer, 64: 1490–1499.3.0.CO;2-L>CrossRefGoogle Scholar
Weidner, N. (1987) Sarcomatoid carcinoma of the upper aerodigestive tract. Seminars in Diagnostic Pathology, 4: 157–168.Google Scholar
Zarbo, R. J., Crissman, J. D., Venkat, H., Weiss, M. A. (1986) Spindle-cell carcinoma of the upper aerodigestive tract mucosa. An immuno-histologic and ultrastructural study of 18 monophasic spindle-cell tumors. American Journal of Surgical Pathology, 10: 741–753.Google Scholar